Protective effect of DL-α-lipoic acid on cyclophosphamide induced oxidative cardiac injury

Y. Mythili, Sudharsan Periyasamy Thandavan, E. Selvakumar, P. Varalakshmi

Research output: Contribution to journalArticle

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Abstract

Cyclophosphamide (CP), one of the most widely prescribed antineoplastic drugs could cause a lethal cardiotoxicity. The present study is aimed at evaluating the role of dl-α-lipoic acid (LA) in oxidative cardiac damage induced by CP. Adult male Wistar rats were divided into four treatment groups. Two groups received single intraperitoneal injection of CP (200 mg/kg BW) to induce cardiotoxicity, one of these groups received LA treatment (25 mg/kg BW for 10 days). A vehicle treated control group and a LA drug control were also included. Cardiotoxicity, evident from increased activities of serum creatine phosphokinase, lactate dehydrogenase, aspartate transaminase and alanine transaminase in CP administered rats, was reversed by LA treatment. CP administered rats showed abnormal levels of enzymic (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione-S- transferase) and non-enzymic antioxidants (glutathione, vitamin C and vitamin E) along with high malondialdehyde levels. However, normalized lipid peroxidation and antioxidant defenses were reported in the LA treated rats. These findings highlight the efficacy of LA as a cytoprotectant in CP induced cardiotoxicity.

Original languageEnglish (US)
Pages (from-to)13-19
Number of pages7
JournalChemico-Biological Interactions
Volume151
Issue number1
DOIs
StatePublished - Dec 30 2004

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Thioctic Acid
Cyclophosphamide
Rats
Wounds and Injuries
Antioxidants
Glutathione Reductase
Drug and Narcotic Control
Creatine Kinase
Glutathione Peroxidase
Aspartate Aminotransferases
Glutathione Transferase
Intraperitoneal Injections
Malondialdehyde
Alanine Transaminase
Vitamin E
L-Lactate Dehydrogenase
Antineoplastic Agents
Catalase
Lipid Peroxidation
Ascorbic Acid

Keywords

  • Antioxidants
  • Cardiotoxicity
  • Cyclophosphamide
  • Lipid peroxidation
  • Lipoic acid

ASJC Scopus subject areas

  • Toxicology

Cite this

Protective effect of DL-α-lipoic acid on cyclophosphamide induced oxidative cardiac injury. / Mythili, Y.; Periyasamy Thandavan, Sudharsan; Selvakumar, E.; Varalakshmi, P.

In: Chemico-Biological Interactions, Vol. 151, No. 1, 30.12.2004, p. 13-19.

Research output: Contribution to journalArticle

Mythili, Y. ; Periyasamy Thandavan, Sudharsan ; Selvakumar, E. ; Varalakshmi, P. / Protective effect of DL-α-lipoic acid on cyclophosphamide induced oxidative cardiac injury. In: Chemico-Biological Interactions. 2004 ; Vol. 151, No. 1. pp. 13-19.
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