Protective effect of reduced glutathione on the liver injury induced by acute omethoate poisoning

Lina Lu, Xiuli Wang, Liwei Lang, Fenghua Fu

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Omethoate is an organophosphate insecticide with high toxicity. The aim of this study was to investigate the protective effect of exogenous reduced glutathione (GSH) on omethoate-induced liver injury. Sprague-Dawley rats were randomly divided into three groups: control, OM (omethoate poisoning), and OM. +. GSH (omethoate poisoning treated with GSH). The activities of acetylcholinesterase (AChE), aspartate aminotransferase (AST), alanine aminotransferase (ALT) in plasma, free organophosphate (FOP) in the liver were determined, and the histopathological changes in the liver were observed. Furthermore, TNF-α and NO in liver homogenate were assayed. The results showed that AChE activity was significantly inhibited by omethoate, but was not altered by GSH treatment. GSH was able to prevent hepatocellular edema and fatty degeneration, decrease liver FOP, attenuate the increased AST and ALT activity, and decline the increase of TNF-α and NO induced by omethoate. These results indicate GSH can attenuate liver injury, and suggest that GSH may be administered to protect the organ from injury in patients with acute organophosphate poisoning.

Original languageEnglish (US)
Pages (from-to)279-283
Number of pages5
JournalEnvironmental Toxicology and Pharmacology
Volume30
Issue number3
DOIs
StatePublished - Nov 2010
Externally publishedYes

Keywords

  • Acetylcholinesterase
  • Acute poisoning
  • Liver injury
  • Omethoate
  • Organophosphate
  • Reduced glutathione

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis

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