Protective effect of steroids in electrolyte-induced demyelination

A. M. Rojiani, J. W. Prineas, E. S. Cho

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Electrolyte-induced demyelination (EID), an experimental model for cen-tral pontine myelinolysis was produced in rats by inducing hyponatremia followed by hypernatremia. There was a marked reduction in the number and size of lesions developing in animals that were bled repeatedly by tail transection during induction of the disease. Subsequently a similar protective effect was produced in animals by injecting a single dose of dexamethasone, one hour before the induction of hyper-natremia. These findings suggest that steroids may be useful in preventing central pontine myelinolysis from developing in high risk patients requiring urgent correction of hyponatremia.

Original languageEnglish (US)
Pages (from-to)495-504
Number of pages10
JournalJournal of Neuropathology and Experimental Neurology
Volume46
Issue number4
DOIs
StatePublished - Jul 1987

Fingerprint

Hyponatremia
Demyelinating Diseases
Electrolytes
Central Pontine Myelinolysis
Steroids
Hypernatremia
Dexamethasone
Tail
Theoretical Models

Keywords

  • Electrolyte-induced demyelination
  • Protective effect
  • Steroids

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Protective effect of steroids in electrolyte-induced demyelination. / Rojiani, A. M.; Prineas, J. W.; Cho, E. S.

In: Journal of Neuropathology and Experimental Neurology, Vol. 46, No. 4, 07.1987, p. 495-504.

Research output: Contribution to journalArticle

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