Protective effects of the carotenoid zeaxanthin in experimental nonalcoholic steatohepatitis

Sherman M Chamberlain, Joshua D. Hall, Jigneshkumar Patel, Jeffrey R Lee, Dennis M. Marcus, Subbaramiah Sridhar, Maritza Josefina Romero Lucas, Mohamed Labazi, Robert William Caldwell, Manuela Bartoli

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Fat infiltration and inflammation cause liver injury and fibrosis and may progress to nonalcoholic steatohepatitis (NASH) and end-stage liver disease. Currently, there are no effective treatments for NASH. Zeaxanthin is a carotenoid which has been shown to be preferentially accumulated in the adipose tissue and liver. We hypothesized that treatment with zeaxanthin may decrease oxidative stress in the liver and, possibly, halt the inflammation and fibrosis associated with NASH. Here we tested zeaxanthin effects in preventing progression of liver injury in a model of NASH. Mongolian gerbils, fed a methionine-choline-deficient diet, were treated with different doses of zeaxanthin. We assessed histopathological changes by hematoxylin-eosin and Masson trichrome staining and determined oxidative stress by measuring lipid peroxidation. The obtained results show that zeaxanthin significantly prevented NASH progression by decreasing oxidative stress and liver fibrosis, thus suggesting a potential therapeutic application for this carotenoid in the management of NASH.

Original languageEnglish (US)
Pages (from-to)1460-1464
Number of pages5
JournalDigestive Diseases and Sciences
Volume54
Issue number7
DOIs
StatePublished - Jul 1 2009

Fingerprint

Carotenoids
Oxidative Stress
Liver Cirrhosis
Liver
Inflammation
End Stage Liver Disease
Gerbillinae
Wounds and Injuries
Hematoxylin
Eosine Yellowish-(YS)
Choline
Methionine
Lipid Peroxidation
Non-alcoholic Fatty Liver Disease
Zeaxanthins
Adipose Tissue
Fibrosis
Fats
Staining and Labeling
Diet

Keywords

  • Carotenoid
  • Fatty liver
  • Fibrosis
  • NASH
  • Oxidative stress
  • Zeaxanthin

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Protective effects of the carotenoid zeaxanthin in experimental nonalcoholic steatohepatitis. / Chamberlain, Sherman M; Hall, Joshua D.; Patel, Jigneshkumar; Lee, Jeffrey R; Marcus, Dennis M.; Sridhar, Subbaramiah; Romero Lucas, Maritza Josefina; Labazi, Mohamed; Caldwell, Robert William; Bartoli, Manuela.

In: Digestive Diseases and Sciences, Vol. 54, No. 7, 01.07.2009, p. 1460-1464.

Research output: Contribution to journalArticle

Chamberlain, Sherman M ; Hall, Joshua D. ; Patel, Jigneshkumar ; Lee, Jeffrey R ; Marcus, Dennis M. ; Sridhar, Subbaramiah ; Romero Lucas, Maritza Josefina ; Labazi, Mohamed ; Caldwell, Robert William ; Bartoli, Manuela. / Protective effects of the carotenoid zeaxanthin in experimental nonalcoholic steatohepatitis. In: Digestive Diseases and Sciences. 2009 ; Vol. 54, No. 7. pp. 1460-1464.
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