TY - JOUR
T1 - Protective role of standardized Feronia limonia stem bark methanolic extract against carbon tetrachloride induced hepatotoxicity
AU - Jain, Mahendra
AU - Kapadia, Rakhee
AU - Jadeja, Ravirajsinh Navalsinh
AU - Thounaojam, Menaka Chanu
AU - Devkar, Ranjitsinh Vijaysinh
AU - Mishra, Shri Hari
PY - 2012
Y1 - 2012
N2 - Objective. This study evaluates hepatoprotective potential of Feronia limonia stem bark (FSB) extracts and fractions using experimental models. Materials and methods. Activity levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and cell viability were evaluated in HepG2 cells treated with car-bon tetrachloride (CCl4) in presence or absence of FL extracts or fractions. Also, plasma markers of hepa-tic damage, hepatic antioxidants, lipid peroxidation and histopathological alterations were assessed in rats treated with CCl4 alone or in combination with 200 or 400 mg/kg bodyweight (BW) of FSB-7 or 25 mg/kg BW of silymarin. Results. In vitro co-supplementation of FSB extracts or fractions recorded varying degree of hepatoprotective potentials. Also, pre-supplementation of FSB methanolic extract (FSB-7) followed by CCl4 treatment significantly prevented hepatic damage and depletion of cellular antioxidants. Also, CCl4+ FSB-7 group showed minimal distortion in the histoarchitecture of liver and results were comparable to that of CCl4+ silymarin treated rats. Conclusion. This inventory is the first scientific report on hepatoprotective potential of FSB methanolic extract.
AB - Objective. This study evaluates hepatoprotective potential of Feronia limonia stem bark (FSB) extracts and fractions using experimental models. Materials and methods. Activity levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and cell viability were evaluated in HepG2 cells treated with car-bon tetrachloride (CCl4) in presence or absence of FL extracts or fractions. Also, plasma markers of hepa-tic damage, hepatic antioxidants, lipid peroxidation and histopathological alterations were assessed in rats treated with CCl4 alone or in combination with 200 or 400 mg/kg bodyweight (BW) of FSB-7 or 25 mg/kg BW of silymarin. Results. In vitro co-supplementation of FSB extracts or fractions recorded varying degree of hepatoprotective potentials. Also, pre-supplementation of FSB methanolic extract (FSB-7) followed by CCl4 treatment significantly prevented hepatic damage and depletion of cellular antioxidants. Also, CCl4+ FSB-7 group showed minimal distortion in the histoarchitecture of liver and results were comparable to that of CCl4+ silymarin treated rats. Conclusion. This inventory is the first scientific report on hepatoprotective potential of FSB methanolic extract.
KW - Antioxidants
KW - Bioassay guided fractions
KW - Histopathology
KW - Marmesin
KW - Silymarin
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U2 - 10.1016/s1665-2681(19)31421-8
DO - 10.1016/s1665-2681(19)31421-8
M3 - Article
C2 - 23109458
AN - SCOPUS:84869459049
SN - 1665-2681
VL - 11
SP - 935
EP - 943
JO - Annals of Hepatology
JF - Annals of Hepatology
IS - 6
ER -