Protective role of standardized Feronia limonia stem bark methanolic extract against carbon tetrachloride induced hepatotoxicity

Mahendra Jain, Rakhee Kapadia, Ravirajsinh Navalsinh Jadeja, Menaka Chanu Thounaojam, Ranjitsinh Vijaysinh Devkar, Shri Hari Mishra

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Objective. This study evaluates hepatoprotective potential of Feronia limonia stem bark (FSB) extracts and fractions using experimental models. Materials and methods. Activity levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and cell viability were evaluated in HepG2 cells treated with car-bon tetrachloride (CCl4) in presence or absence of FL extracts or fractions. Also, plasma markers of hepa-tic damage, hepatic antioxidants, lipid peroxidation and histopathological alterations were assessed in rats treated with CCl4 alone or in combination with 200 or 400 mg/kg bodyweight (BW) of FSB-7 or 25 mg/kg BW of silymarin. Results. In vitro co-supplementation of FSB extracts or fractions recorded varying degree of hepatoprotective potentials. Also, pre-supplementation of FSB methanolic extract (FSB-7) followed by CCl4 treatment significantly prevented hepatic damage and depletion of cellular antioxidants. Also, CCl4+ FSB-7 group showed minimal distortion in the histoarchitecture of liver and results were comparable to that of CCl4+ silymarin treated rats. Conclusion. This inventory is the first scientific report on hepatoprotective potential of FSB methanolic extract.

Original languageEnglish (US)
Pages (from-to)935-943
Number of pages9
JournalAnnals of Hepatology
Volume11
Issue number6
StatePublished - Nov 26 2012

Keywords

  • Antioxidants
  • Bioassay guided fractions
  • Histopathology
  • Marmesin
  • Silymarin

ASJC Scopus subject areas

  • Hepatology

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