Abstract
As the predominant cellular receptor for phorbol esters, protein kinase C (PKC) is assumed to play a role in epidermal carcinogenesis. Nevertheless, determining its exact role in keratinocytes has been difficult because of the existence of multiple PKC isoforms and the inherent weaknesses in methodologies used to investigate their function. In this issue, Jerome-Morais et al. describe their use of multiple in vitro, in situ, overexpression, and knockdown approaches to demonstrate that PKCα induces keratinocyte growth arrest.
Original language | English (US) |
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Pages (from-to) | 2330-2332 |
Number of pages | 3 |
Journal | Journal of Investigative Dermatology |
Volume | 129 |
Issue number | 10 |
DOIs |
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State | Published - Oct 2009 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Dermatology
- Cell Biology