TY - JOUR
T1 - Protein tyrosine kinases in neutrophil activation and recruitment
AU - Zarbock, Alexander
AU - Ley, Klaus
N1 - Funding Information:
A.Z. is supported by grants from the German Research Foundation (DFG AZ 428/3-1, AZ 428/5-1) and the Interdisciplinary Clinical Research Center (IZKF, ZA2/001/10) (Muenster, Germany).
PY - 2011/6/15
Y1 - 2011/6/15
N2 - Migration of leukocytes into tissue is a key element of innate and adaptive immunity. The first contact of leukocytes with endothelial cells is mediated by engagement of selectins with their counter-receptors which results in leukocyte rolling. During rolling, leukocytes collect different inflammatory signals that activate intracellular signaling pathways. Integration of these signals induces leukocyte activation, firm arrest, post-adhesion strengthening, intravascular crawling, and transmigration. In neutrophils, like in T-cells and platelets, both G-protein-coupled receptor-dependent and -independent activation pathways exist that lead to integrin activation. Accumulating evidence suggests that different protein tyrosine kinases play key roles in signal transduction pathways regulating neutrophil activation and recruitment to inflammatory sites. This review focuses on the role of protein tyrosine kinases of the Src, Syk, and Tec families for neutrophil activation and recruitment.
AB - Migration of leukocytes into tissue is a key element of innate and adaptive immunity. The first contact of leukocytes with endothelial cells is mediated by engagement of selectins with their counter-receptors which results in leukocyte rolling. During rolling, leukocytes collect different inflammatory signals that activate intracellular signaling pathways. Integration of these signals induces leukocyte activation, firm arrest, post-adhesion strengthening, intravascular crawling, and transmigration. In neutrophils, like in T-cells and platelets, both G-protein-coupled receptor-dependent and -independent activation pathways exist that lead to integrin activation. Accumulating evidence suggests that different protein tyrosine kinases play key roles in signal transduction pathways regulating neutrophil activation and recruitment to inflammatory sites. This review focuses on the role of protein tyrosine kinases of the Src, Syk, and Tec families for neutrophil activation and recruitment.
KW - Integrin
KW - Leukocyte recruitment
KW - Protein tyrosine kinase
KW - Signaling
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U2 - 10.1016/j.abb.2011.02.009
DO - 10.1016/j.abb.2011.02.009
M3 - Article
AN - SCOPUS:79958724618
SN - 0003-9861
VL - 510
SP - 112
EP - 119
JO - Archives of Biochemistry and Biophysics
JF - Archives of Biochemistry and Biophysics
IS - 2
ER -