Protocol for behavioral and neural recording during stimulation of the macaque monkey nucleus basalis

Xue Lian Qi, Kendyl R. Pennington, Christopher Banerjee, Fernando L. Vale, Sarah K. Bick, Dario J. Englot, Robert S. Turner, Christos Constantinidis, David T. Blake

Research output: Contribution to journalArticlepeer-review

Abstract

We present an experimental protocol to record neuronal activity during intermittent stimulation of nucleus basalis (NB), as macaque monkeys perform cognitive tasks. This protocol includes implantation of electrodes and generator devices to deliver electrical stimulation to NB using multiple approaches in monkeys. Direct stimulation of NB avoids peripheral cholinergic side effects, optimizes timing, and activates non-cholinergic projection neurons. We describe electrode preparation, surgery, and implantation for direct evaluation of how stimulation affects monkeys’ behavior and neuronal activity. For complete details on the use and execution of this profile, please refer to Qi et al. (2021).

Original languageEnglish (US)
Article number101136
JournalSTAR Protocols
Volume3
Issue number1
DOIs
StatePublished - Mar 18 2022
Externally publishedYes

Keywords

  • Behavior
  • Cognitive Neuroscience
  • Model Organisms
  • Neuroscience

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology
  • General Neuroscience

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