@article{8150e3974cff4b0b9daacbdc7bc386a6,
title = "Protocol for behavioral and neural recording during stimulation of the macaque monkey nucleus basalis",
abstract = "We present an experimental protocol to record neuronal activity during intermittent stimulation of nucleus basalis (NB), as macaque monkeys perform cognitive tasks. This protocol includes implantation of electrodes and generator devices to deliver electrical stimulation to NB using multiple approaches in monkeys. Direct stimulation of NB avoids peripheral cholinergic side effects, optimizes timing, and activates non-cholinergic projection neurons. We describe electrode preparation, surgery, and implantation for direct evaluation of how stimulation affects monkeys{\textquoteright} behavior and neuronal activity. For complete details on the use and execution of this profile, please refer to Qi et al. (2021).",
keywords = "Behavior, Cognitive Neuroscience, Model Organisms, Neuroscience",
author = "Qi, {Xue Lian} and Pennington, {Kendyl R.} and Christopher Banerjee and Vale, {Fernando L.} and Bick, {Sarah K.} and Englot, {Dario J.} and Turner, {Robert S.} and Christos Constantinidis and Blake, {David T.}",
note = "Funding Information: This work was supported by NIH grants RF1AG060754 and R01MH097695. We wish to thank Chrissy Suell, Katelyn Clemencich, and Gracie Hilber for outstanding technical help. Paul Korinko, PhD provided equipment guidance and a microwelding tutorial to D.T.B, for this method. Alvin Terry kindly provided the photo for Figure 6. R.S.T. developed the electrode manufacturing methods, guide tube/stylus implantation methods, and communicated those to D.T.B. D.T.B. developed the bone screw with Gray Matter Research, Bozeman, MT. Methods for IPG placement, tunneling, and welding in the monkey were developed by D.T.B. F.V.D. C.B. and K.R.P. and refined by S.B. and D.E. Guide tube/stylus electrode placement was adapted by D.T.B. and K.R.P. Adaptations for recording were developed by C.C. and X.Q. C.C. and D.T.B. oversaw all development and were in regular communication as these methods matured. The authors have received stimulator devices from Boston Scientific through a Materials Transfer Agreement. Funding Information: This work was supported by NIH grants RF1AG060754 and R01MH097695 . We wish to thank Chrissy Suell, Katelyn Clemencich, and Gracie Hilber for outstanding technical help. Paul Korinko, PhD provided equipment guidance and a microwelding tutorial to D.T.B, for this method. Alvin Terry kindly provided the photo for Figure 6 . Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2022",
month = mar,
day = "18",
doi = "10.1016/j.xpro.2022.101136",
language = "English (US)",
volume = "3",
journal = "STAR Protocols",
issn = "2666-1667",
publisher = "Cell Press",
number = "1",
}