Provincial distribution of three HIV-1 resistant polymorphisms (CCR5- Δ 32, CCR2-64I, and SDF1-3′ A) in China

Junhua Xiao, Fang Hu, Hongyan Xu, Bing Su, Yueming Jiang, Jingchun Luo, Weiling Zhang, Jiazhen Tan, Li Jin, Daru Lu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

CCR5- Δ 32, CCR2-64I, mutants in two chemokine receptors and SDF1-3′ A, mutant in a ligand gene, can delay AIDS pathogenesis. The distribution of the three polymorphic loci was studied in 1 046 DNA samples from 26 provinces (cities) in China. No CCR5-Δ 32 was observed. CCR2-64I and SDF1-3′ A had reverse distribution cline from south to north in China, with average frequency of 20.8% and 24.8% respectively. Relative hazard was evaluated. Important information to the epidemiology of AIDS and the origin and spread of these polymorphic loci in Chinese was provided.

Original languageEnglish (US)
Pages (from-to)19-20
Number of pages2
JournalScience in China, Series C: Life Sciences
Volume43
Issue number1
StatePublished - Dec 1 2000
Externally publishedYes

Fingerprint

Chemokine CXCL12
acquired immune deficiency syndrome
human immunodeficiency virus
Human immunodeficiency virus 1
Polymorphism
HIV-1
China
Acquired Immunodeficiency Syndrome
polymorphism
genetic polymorphism
mutants
Epidemiology
loci
cline
Chemokine Receptors
epidemiology
ligand
Hazards
pathogenesis
Genes

Keywords

  • AIDS
  • HIV-1
  • PCR-RFLP

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

Cite this

Provincial distribution of three HIV-1 resistant polymorphisms (CCR5- Δ 32, CCR2-64I, and SDF1-3′ A) in China. / Xiao, Junhua; Hu, Fang; Xu, Hongyan; Su, Bing; Jiang, Yueming; Luo, Jingchun; Zhang, Weiling; Tan, Jiazhen; Jin, Li; Lu, Daru.

In: Science in China, Series C: Life Sciences, Vol. 43, No. 1, 01.12.2000, p. 19-20.

Research output: Contribution to journalArticle

Xiao, J, Hu, F, Xu, H, Su, B, Jiang, Y, Luo, J, Zhang, W, Tan, J, Jin, L & Lu, D 2000, 'Provincial distribution of three HIV-1 resistant polymorphisms (CCR5- Δ 32, CCR2-64I, and SDF1-3′ A) in China', Science in China, Series C: Life Sciences, vol. 43, no. 1, pp. 19-20.
Xiao, Junhua ; Hu, Fang ; Xu, Hongyan ; Su, Bing ; Jiang, Yueming ; Luo, Jingchun ; Zhang, Weiling ; Tan, Jiazhen ; Jin, Li ; Lu, Daru. / Provincial distribution of three HIV-1 resistant polymorphisms (CCR5- Δ 32, CCR2-64I, and SDF1-3′ A) in China. In: Science in China, Series C: Life Sciences. 2000 ; Vol. 43, No. 1. pp. 19-20.
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AU - Su, Bing

AU - Jiang, Yueming

AU - Luo, Jingchun

AU - Zhang, Weiling

AU - Tan, Jiazhen

AU - Jin, Li

AU - Lu, Daru

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AB - CCR5- Δ 32, CCR2-64I, mutants in two chemokine receptors and SDF1-3′ A, mutant in a ligand gene, can delay AIDS pathogenesis. The distribution of the three polymorphic loci was studied in 1 046 DNA samples from 26 provinces (cities) in China. No CCR5-Δ 32 was observed. CCR2-64I and SDF1-3′ A had reverse distribution cline from south to north in China, with average frequency of 20.8% and 24.8% respectively. Relative hazard was evaluated. Important information to the epidemiology of AIDS and the origin and spread of these polymorphic loci in Chinese was provided.

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