Provincial distribution of three HIV-1 resistant polymorphisms (CCR5- Δ 32, CCR2-64I, and SDF1-3′ A) in China

Junhua Xiao, Fang Hu, Hongyan Xu, Bing Su, Yueming Jiang, Jingchun Luo, Weiling Zhang, Jiazhen Tan, Li Jin, Daru Lu

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

CCR5- Δ 32, CCR2-64I, mutants in two chemokine receptors and SDF1-3′ A, mutant in a ligand gene, can delay AIDS pathogenesis. The distribution of the three polymorphic loci was studied in 1 046 DNA samples from 26 provinces (cities) in China. No CCR5-Δ 32 was observed. CCR2-64I and SDF1-3′ A had reverse distribution cline from south to north in China, with average frequency of 20.8% and 24.8% respectively. Relative hazard was evaluated. Important information to the epidemiology of AIDS and the origin and spread of these polymorphic loci in Chinese was provided.

Original languageEnglish (US)
Pages (from-to)16-20
Number of pages5
JournalScience in China, Series C: Life Sciences
Volume43
Issue number1
StatePublished - Jan 1 2000
Externally publishedYes

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Keywords

  • AIDS
  • HIV-1
  • PCR-RFLP

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

Cite this

Xiao, J., Hu, F., Xu, H., Su, B., Jiang, Y., Luo, J., Zhang, W., Tan, J., Jin, L., & Lu, D. (2000). Provincial distribution of three HIV-1 resistant polymorphisms (CCR5- Δ 32, CCR2-64I, and SDF1-3′ A) in China. Science in China, Series C: Life Sciences, 43(1), 16-20.