TY - JOUR
T1 - Pterocarpus marsupium Roxburgh heartwood extract/chitosan nanoparticles loaded hydrogel as an innovative wound healing agent in the diabetic rat model
AU - Manne, Anupama Ammulu
AU - Arigela, Bharathi
AU - Giduturi, Ajay Kumar
AU - Komaravolu, Ravi K.
AU - Mangamuri, Ushakiranmayi
AU - Poda, Sudhakar
N1 - Funding Information:
The authors thank the Federal Ministry of the Interior, Building and Community (Bundesministerium des Innern, für Bau und Heimat) of the Federal Republic of Germany and the Manfred Donike Institute for Doping Analysis (Manfred‐Donike Institut für Dopinganalytik e.V.), Cologne, for supporting the presented work. Open Access funding enabled and organized by Projekt DEAL.
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2021/3
Y1 - 2021/3
N2 - The application of modern nanomedicines to enhance wound healing is growing due to their simplicity for topical organization and fast flexibility with molecules that can boost and reinforce the process of healing even in patients with diabetes. The point of the present investigation was to synthesize effective Pterocarpus marsupium heartwood extract/chitosan nanoparticles (PM-CNPs) loaded hydrogel (PM-CNPsH) and evaluate its drug release efficiency, in-vitro anti-microbial activity and wound healing action in streptozotocin administered diabetic rat models. The prepared PM-CNPs further utilized for the preparation of various carbopol hydrogel formulations. Hence, prepared hydrogels are characterized for pH, morphology, consistency, and spreadability; thus, PM-CNPsH-1 is found to be the optimized formulation. In-vivo rats treated with PM-CNPsH-1 displayed significantly much quicker healing of wounds in diabetic and non-diabetic rats. The histological examination revealed re-epithelization and growth of granular tissue and an improvement in collagen deposition. These results indicate the effectiveness of optimized nanocomposites as a potential treatment for curing diabetic wounds.
AB - The application of modern nanomedicines to enhance wound healing is growing due to their simplicity for topical organization and fast flexibility with molecules that can boost and reinforce the process of healing even in patients with diabetes. The point of the present investigation was to synthesize effective Pterocarpus marsupium heartwood extract/chitosan nanoparticles (PM-CNPs) loaded hydrogel (PM-CNPsH) and evaluate its drug release efficiency, in-vitro anti-microbial activity and wound healing action in streptozotocin administered diabetic rat models. The prepared PM-CNPs further utilized for the preparation of various carbopol hydrogel formulations. Hence, prepared hydrogels are characterized for pH, morphology, consistency, and spreadability; thus, PM-CNPsH-1 is found to be the optimized formulation. In-vivo rats treated with PM-CNPsH-1 displayed significantly much quicker healing of wounds in diabetic and non-diabetic rats. The histological examination revealed re-epithelization and growth of granular tissue and an improvement in collagen deposition. These results indicate the effectiveness of optimized nanocomposites as a potential treatment for curing diabetic wounds.
KW - Anti-bacterial
KW - Chitosan nanoparticles
KW - Diabetic wound healing
KW - Histological analysis
KW - Pterocarpus marsupium Rox.b
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U2 - 10.1016/j.mtcomm.2020.101916
DO - 10.1016/j.mtcomm.2020.101916
M3 - Article
AN - SCOPUS:85097464316
SN - 2352-4928
VL - 26
JO - Materials Today Communications
JF - Materials Today Communications
M1 - 101916
ER -
