Pulmonary and systemic fluid filtration after continuous versus bolus interleukin-2 infusion

B. A. Harms, D. J. Rosenfeld, R. L. Conhaim, A. C. Pahl, Ramiah Subramanian, F. K. Storm

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Abstract

Interleukin-2 has been widely investigated as adjuvant therapy for advanced cancer and is administered by either bolus or continuous infusion. We compared the effects of bolus and continuous interleukin-2 infusion on pulmonary (Q(L)) and systemic microvascular fluid filtration in 11 adult sheep prepared with chronic lung and soft-tissue lymph fistulas. Interleukin-2 was administered as a bolus infusion (100,000 units/kg) every 8 hours for 3 days or as a continuous infusion at the same dose for 3 days. No significant changes in pulmonary hydrostatic pressures or pulmonary vascular resistance were noted after either bolus or continuous interleukin-2 infusion. However, significantly decreased (p ≤ 0.05) systemic vascular resistances were observed in both groups. Q(L) increased steadily throughout the infusion period in both groups, peaking at three times baseline on the third infusion day. The plasma/interstitial protein clearance (Q(L) x lymph/plasma protein ratio) rose similarly in both groups, indicating increased barrier permeability. Increased lymphocyte clearance into lung lymph occurred by day 3 but was not associated with lymphocytic sequestration in the lung interstitium. We conclude that pulmonary and systemic microvascular fluid and protein flux exhibit similar changes after bolus or continuous interleukin-2 infusion. These changes are associated with increased clearance of lymphocytes into lung lymph that are not sequestered in the pulmonary interstitium after infusions of shorter duration.

Original languageEnglish (US)
Pages (from-to)500-507
Number of pages8
JournalSurgery
Volume110
Issue number3
Publication statusPublished - Jan 1 1991

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ASJC Scopus subject areas

  • Surgery

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Harms, B. A., Rosenfeld, D. J., Conhaim, R. L., Pahl, A. C., Subramanian, R., & Storm, F. K. (1991). Pulmonary and systemic fluid filtration after continuous versus bolus interleukin-2 infusion. Surgery, 110(3), 500-507.