Pulmonary embolism

Emboli and fibrinolysis inhibition in isolated canine lungs

M. I. Townsley, Scott A Barman, A. E. Taylor

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The effect of fibrinolysis inhibition with tranexamic acid on pulmonary microvascular permeability during glass bead embolization was investigated in the isolated lung. Lung lobes from nonheparinized dogs were treated in vivo with the equivalent of 0.6 g/kg 100 μm glass bead emboli alone, emboli after tranexamic acid, tranexamic acid alone, or the bead vehicle alone. After 40-50 min, the lobes were isolated for ex vivo perfusion with heparinized autologous blood. There were no changes in any parameter over the 120-min perfusion period. Blood flow at 120 min was decreased after both emboli alone and emboli with tranexamic acid, reflecting an increase in vascular resistance compared with the Tween or tranexamic acid controls. Furthermore, tranexamic acid increased the ratio of pre- to postcapillary resistance in embolized lobes compared with that after emboli alone or in the Tween or tranexamic acid controls. The isogravimetric capillary pressure and the osmotic reflection coefficient were not significantly decreased by tranexamic acid compared with those after emboli alone; however, it did result in an increase in the capillary filtration coefficient compared with that after emboli alone or in the control groups. We conclude that although fibrinolysis inhibition does not clearly exacerbate the lung injury seen after emboli, the tranexamic acid-induced changes in hemodynamics would tend to accelerate edema formation.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume258
Issue number3 27-3
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Tranexamic Acid
Fibrinolysis
Embolism
Pulmonary Embolism
Canidae
Lung
Polysorbates
Glass
Perfusion
Osmotic Pressure
Capillary Permeability
Lung Injury
Vascular Resistance
Edema
Hemodynamics
Dogs
Control Groups

Keywords

  • capillary filtration coefficient
  • isogravimetric capillary pressure
  • osmotic reflection coefficient
  • osmotic transient
  • tranexamic acid

ASJC Scopus subject areas

  • Physiology

Cite this

Pulmonary embolism : Emboli and fibrinolysis inhibition in isolated canine lungs. / Townsley, M. I.; Barman, Scott A; Taylor, A. E.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 258, No. 3 27-3, 01.01.1990.

Research output: Contribution to journalArticle

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