Pupillary response to cognitive workload during saccadic tasks in Parkinson's disease

M. Ranchet, J. Orlosky, J. Morgan, S. Qadir, A. E. Akinwuntan, H. Devos

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The relationship between cognitive workload and cognitive impairments in Parkinson's disease (PD) is currently not well known. This study compared cognitive workload during saccadic tasks between patients with PD and controls. Sixteen controls, 11 patients with no obvious cognitive impairment (PD-NCI) (MOCA score ≥ 26), and 10 PD patients with cognitive impairment (PD-CI) (MOCA score < 26) performed prosaccade and antisaccade tasks. Cognitive workload, extracted via pupil recording, and other eye metrics were compared between the three groups. PD-NCI patients exhibited greater cognitive workload than controls in the prosaccade task. PD-CI patients also showed more cognitive workload in the prosaccade task than PD-NCI patients and controls. No other differences in eye metrics were found between the three groups. Cognitive workload could be used to differentiate between different cognitive states in PD. The causal relationship between increased cognitive workload and cognitive decline in PD-NCI should be the focus of future studies.

Original languageEnglish (US)
Pages (from-to)162-166
Number of pages5
JournalBehavioural Brain Research
Volume327
DOIs
StatePublished - Jun 1 2017

Fingerprint

Workload
Parkinson Disease
Methylenebis(chloroaniline)
Pupil
Cognitive Dysfunction

Keywords

  • Antisaccade task
  • Cognitive workload
  • Executive function
  • Parkinson's disease
  • Prosaccade task

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Pupillary response to cognitive workload during saccadic tasks in Parkinson's disease. / Ranchet, M.; Orlosky, J.; Morgan, J.; Qadir, S.; Akinwuntan, A. E.; Devos, H.

In: Behavioural Brain Research, Vol. 327, 01.06.2017, p. 162-166.

Research output: Contribution to journalArticle

Ranchet, M. ; Orlosky, J. ; Morgan, J. ; Qadir, S. ; Akinwuntan, A. E. ; Devos, H. / Pupillary response to cognitive workload during saccadic tasks in Parkinson's disease. In: Behavioural Brain Research. 2017 ; Vol. 327. pp. 162-166.
@article{ade93bbbc5ed4d7ca06778afbbc79414,
title = "Pupillary response to cognitive workload during saccadic tasks in Parkinson's disease",
abstract = "The relationship between cognitive workload and cognitive impairments in Parkinson's disease (PD) is currently not well known. This study compared cognitive workload during saccadic tasks between patients with PD and controls. Sixteen controls, 11 patients with no obvious cognitive impairment (PD-NCI) (MOCA score ≥ 26), and 10 PD patients with cognitive impairment (PD-CI) (MOCA score < 26) performed prosaccade and antisaccade tasks. Cognitive workload, extracted via pupil recording, and other eye metrics were compared between the three groups. PD-NCI patients exhibited greater cognitive workload than controls in the prosaccade task. PD-CI patients also showed more cognitive workload in the prosaccade task than PD-NCI patients and controls. No other differences in eye metrics were found between the three groups. Cognitive workload could be used to differentiate between different cognitive states in PD. The causal relationship between increased cognitive workload and cognitive decline in PD-NCI should be the focus of future studies.",
keywords = "Antisaccade task, Cognitive workload, Executive function, Parkinson's disease, Prosaccade task",
author = "M. Ranchet and J. Orlosky and J. Morgan and S. Qadir and Akinwuntan, {A. E.} and H. Devos",
year = "2017",
month = "6",
day = "1",
doi = "10.1016/j.bbr.2017.03.043",
language = "English (US)",
volume = "327",
pages = "162--166",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",

}

TY - JOUR

T1 - Pupillary response to cognitive workload during saccadic tasks in Parkinson's disease

AU - Ranchet, M.

AU - Orlosky, J.

AU - Morgan, J.

AU - Qadir, S.

AU - Akinwuntan, A. E.

AU - Devos, H.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - The relationship between cognitive workload and cognitive impairments in Parkinson's disease (PD) is currently not well known. This study compared cognitive workload during saccadic tasks between patients with PD and controls. Sixteen controls, 11 patients with no obvious cognitive impairment (PD-NCI) (MOCA score ≥ 26), and 10 PD patients with cognitive impairment (PD-CI) (MOCA score < 26) performed prosaccade and antisaccade tasks. Cognitive workload, extracted via pupil recording, and other eye metrics were compared between the three groups. PD-NCI patients exhibited greater cognitive workload than controls in the prosaccade task. PD-CI patients also showed more cognitive workload in the prosaccade task than PD-NCI patients and controls. No other differences in eye metrics were found between the three groups. Cognitive workload could be used to differentiate between different cognitive states in PD. The causal relationship between increased cognitive workload and cognitive decline in PD-NCI should be the focus of future studies.

AB - The relationship between cognitive workload and cognitive impairments in Parkinson's disease (PD) is currently not well known. This study compared cognitive workload during saccadic tasks between patients with PD and controls. Sixteen controls, 11 patients with no obvious cognitive impairment (PD-NCI) (MOCA score ≥ 26), and 10 PD patients with cognitive impairment (PD-CI) (MOCA score < 26) performed prosaccade and antisaccade tasks. Cognitive workload, extracted via pupil recording, and other eye metrics were compared between the three groups. PD-NCI patients exhibited greater cognitive workload than controls in the prosaccade task. PD-CI patients also showed more cognitive workload in the prosaccade task than PD-NCI patients and controls. No other differences in eye metrics were found between the three groups. Cognitive workload could be used to differentiate between different cognitive states in PD. The causal relationship between increased cognitive workload and cognitive decline in PD-NCI should be the focus of future studies.

KW - Antisaccade task

KW - Cognitive workload

KW - Executive function

KW - Parkinson's disease

KW - Prosaccade task

UR - http://www.scopus.com/inward/record.url?scp=85017181474&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017181474&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2017.03.043

DO - 10.1016/j.bbr.2017.03.043

M3 - Article

C2 - 28366772

AN - SCOPUS:85017181474

VL - 327

SP - 162

EP - 166

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

ER -