PYK2 and FAK in osteoclasts.

Wen Cheng Xiong; X. Feng

doi:10.2741/1117

PYK2 and FAK in osteoclasts.

Wen Cheng Xiong, X. Feng

Graduate Studies

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Integrin alpha(v)beta3 plays a pivotal role in osteoclastic bone resoprtion by mediating both osteoclast attachments on bone matrix and cytoskeleton reorganization. The focal adhesion kinase (FAK) family kinases including FAK and proline-rich tyrosine kinase 2 (PYK2) are major tyrosine kinases activated by integrin engagement. In osteoclasts, although FAK is expressed, PYK2 appears to be the predominant mediator of integrin alpha(v)beta3 signaling events that influence osteoclast physiology and pathology. Recent progress in the understanding of the role of PYK2/FAK kinases in the regulation of osteoclastic actin cytoskeletal organization, cell migration, and bone resorption will be discussed in this review.

Original language	English (US)
Pages (from-to)	d1219-1226
Journal	Frontiers in bioscience : a journal and virtual library
Volume	8
DOIs	https://doi.org/10.2741/1117
State	Published - Sep 1 2003

Keywords

FAK
Integrins
Osteoclasts
PYK2
Review
Signaling

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Biochemistry
Cell Biology

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10.2741/1117

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title = "PYK2 and FAK in osteoclasts.",

abstract = "Integrin alpha(v)beta3 plays a pivotal role in osteoclastic bone resoprtion by mediating both osteoclast attachments on bone matrix and cytoskeleton reorganization. The focal adhesion kinase (FAK) family kinases including FAK and proline-rich tyrosine kinase 2 (PYK2) are major tyrosine kinases activated by integrin engagement. In osteoclasts, although FAK is expressed, PYK2 appears to be the predominant mediator of integrin alpha(v)beta3 signaling events that influence osteoclast physiology and pathology. Recent progress in the understanding of the role of PYK2/FAK kinases in the regulation of osteoclastic actin cytoskeletal organization, cell migration, and bone resorption will be discussed in this review.",

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AU - Feng, X.

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AB - Integrin alpha(v)beta3 plays a pivotal role in osteoclastic bone resoprtion by mediating both osteoclast attachments on bone matrix and cytoskeleton reorganization. The focal adhesion kinase (FAK) family kinases including FAK and proline-rich tyrosine kinase 2 (PYK2) are major tyrosine kinases activated by integrin engagement. In osteoclasts, although FAK is expressed, PYK2 appears to be the predominant mediator of integrin alpha(v)beta3 signaling events that influence osteoclast physiology and pathology. Recent progress in the understanding of the role of PYK2/FAK kinases in the regulation of osteoclastic actin cytoskeletal organization, cell migration, and bone resorption will be discussed in this review.

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KW - Osteoclasts

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KW - Review

KW - Signaling

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PYK2 and FAK in osteoclasts.

Abstract

Keywords

ASJC Scopus subject areas

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