Quadrivalent HPV vaccine efficacy against disease related to vaccine and non-vaccine HPV types in males

Stephen E. Goldstone, Heiko Jessen, Joel M. Palefsky, Anna R. Giuliano, Edson D. Moreira, Eftyhia Vardas, Carlos Aranda, Richard J. Hillman, Daron G. Ferris, Francois Coutlee, J. Brooke Marshall, Scott Vuocolo, Richard M. Haupt, Dalya Guris, Elizabeth Garner

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

A small number of HPV types are related to a majority of HPV-related neoplastic lesions in humans. High-risk types such as HPV 16 and 18 are most often implicated, although other oncogenic and non-oncogenic HPV types can cause disease in men. The efficacy of the quadrivalent HPV vaccine (qHPV) against external genital lesions and intra-anal disease related to HPV in men has been demonstrated. This report examines the vaccine's efficacy against disease due to 10 additional non-vaccine HPV types, as well as efficacy regardless of HPV detection. The data presented suggest that vaccinating males against HPV 6, 11, 16 and 18 protects them against most vaccine HPV-type related anogenital disease. However, significant efficacy against disease due to non-vaccine HPV types was not seen. In addition, the data do not provide any evidence that vaccination with qHPV vaccine will increase the likelihood of disease caused by non-vaccine types in the short term.

Original languageEnglish (US)
Pages (from-to)3849-3855
Number of pages7
JournalVaccine
Volume31
Issue number37
DOIs
StatePublished - Aug 20 2013

Keywords

  • HPV
  • Males
  • Men who have sex with men
  • Young

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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  • Cite this

    Goldstone, S. E., Jessen, H., Palefsky, J. M., Giuliano, A. R., Moreira, E. D., Vardas, E., Aranda, C., Hillman, R. J., Ferris, D. G., Coutlee, F., Marshall, J. B., Vuocolo, S., Haupt, R. M., Guris, D., & Garner, E. (2013). Quadrivalent HPV vaccine efficacy against disease related to vaccine and non-vaccine HPV types in males. Vaccine, 31(37), 3849-3855. https://doi.org/10.1016/j.vaccine.2013.06.057