Quality of life for children and adolescents

Impact of HIV infection and antiretroviral treatment

Grace M. Lee, Steven L. Gortmaker, Kenneth McIntosh, Michael D. Hughes, James M. Oleske, P. Palumbo, P. Andrew, A. Dieudonne, B. Dashefsky, S. Gaur, P. Whitley-Williams, A. Malhotra, L. Cerracchio, M. Keller, J. Hayes, A. Gagajena, C. Mink, N. Hutton, B. Griffith, M. Joyner & 91 others C. Kiefner, F. Minglana, M. E. Paul, W. T. Shearer, C. D. Jackson, D. C. Johnson, D. Kowalski, B. Wolfe, D. Ryan, A. Higgins, M. Foca, P. LaRussa, A. Gershon, G. B. Scott, C. D. Mitchell, L. Taybo, C. Gamber, A. Petru, T. Courville, K. Gold, L. Johnson, J. P. Piatt, J. Foti, L. Clarke-Steffen, T. Belho, B. Pitkin, J. Eddleman, V. R. Bonagura, S. J. Schuval, C. Colter, E. J. Abrams, M. Frere, D. Calo, S. Champion, E. Handelsman, H. J. Moallem, D. M. Swindell, J. M. Kaye, M. Chin, K. Dorio, A. Wiznia, M. Donovan, M. Acevedo, M. Gonzalez, L. Fabregas, M. E. Texidor, W. A. Andiman, S. Romano, L. Hurst, J. De Jesus, L. B. Weiner, K. A. Contello, W. A. Holz, M. J. Famiglietti, S. Nachman, D. Nikolic-Djokic, D. Ferraro, J. Perillo, S. Rana, H. Finke-Castro, P. H. Yu, J. C. Roa, M. H. Rathore, A. Khayat, K. Champion, S. Cusic, P. M. Flynn, K. Knapp, N. Patel, G. Wilson, K. A. McGann, L. Pickering, G. A. Storch, S. D. Douglas, G. Koutsoubis, R. M. Rutstein, C. A. Vincent, M. Silio, T. Alchediak, C. Boe, M. Cowie, B. W. Stechenberg, D. J. Fisher, A. M. Johnston, M. Toye, Chitra S Mani, S. Foshee, B. Kiean, S. Cobb, J. Farley, K. Klipner

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

BACKGROUND. HIV/AIDS mortality rates in the United States are declining; pediatric HIV has become a chronic disease, with quality of life (QoL) outcomes assuming greater importance. OBJECTIVES. To compare QoL among HIV-infected and uninfected children and to assess the impact of different antiretroviral regimens on QoL among HIV-infected children. METHODS. Perinatally exposed, HIV-infected (N = 1847) and uninfected (N = 712) children and adolescents were studied. Among infected children, 1283 were available for the antiretroviral regimen analysis. QoL domain scores were assessed for subjects 6 months to 4 years, 5 to 11 years, and 12 to 21 years of age, and the impact of infection status and alternative treatment regimens on QoL domains was evaluated. RESULTS. HIV infection was associated with significantly worse mean adjusted scores for functional status among children 6 months to 4 years of age and health perceptions, physical resilience, physical functioning, and social/role functioning among those 5 to 11 years of age. However, uninfected children 5 to 11 years of age reported significantly worse psychological functioning. HIV-infected children (5-11 years of age) and adolescents (12-21 years of age) receiving no antiretroviral treatment had worse health perceptions. Adolescents receiving no antiretroviral agents also had worse symptoms. When antiretroviral regimens were compared, adolescents receiving protease inhibitor plus nonnucleoside reverse transcriptase inhibitor-containing therapy had worse symptoms, compared with those receiving protease inhibitor-containing therapy; otherwise, no significant differences were found. CONCLUSIONS. Generally parents of HIV-infected children 6 months to 4 years and 5 to 11 years of age generally reported lower mean QoL scores than did parents of uninfected children, although worse psychological functioning was reported for uninfected children. HIV-infected adolescents not receiving antiretroviral treatment had worse health perceptions and symptoms. We found no consistent QoL differences among children receiving different antiretroviral regimens.

Original languageEnglish (US)
Pages (from-to)273-283
Number of pages11
JournalPediatrics
Volume117
Issue number2
DOIs
StatePublished - Feb 1 2006

Fingerprint

HIV Infections
Quality of Life
HIV
Therapeutics
Protease Inhibitors
Health
Parents
Psychology
Anti-Retroviral Agents
Reverse Transcriptase Inhibitors
Acquired Immunodeficiency Syndrome
Chronic Disease
Pediatrics
Mortality
Infection

Keywords

  • Antiretroviral therapy
  • HIV
  • Quality of life

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Lee, G. M., Gortmaker, S. L., McIntosh, K., Hughes, M. D., Oleske, J. M., Palumbo, P., ... Klipner, K. (2006). Quality of life for children and adolescents: Impact of HIV infection and antiretroviral treatment. Pediatrics, 117(2), 273-283. https://doi.org/10.1542/peds.2005-0323

Quality of life for children and adolescents : Impact of HIV infection and antiretroviral treatment. / Lee, Grace M.; Gortmaker, Steven L.; McIntosh, Kenneth; Hughes, Michael D.; Oleske, James M.; Palumbo, P.; Andrew, P.; Dieudonne, A.; Dashefsky, B.; Gaur, S.; Whitley-Williams, P.; Malhotra, A.; Cerracchio, L.; Keller, M.; Hayes, J.; Gagajena, A.; Mink, C.; Hutton, N.; Griffith, B.; Joyner, M.; Kiefner, C.; Minglana, F.; Paul, M. E.; Shearer, W. T.; Jackson, C. D.; Johnson, D. C.; Kowalski, D.; Wolfe, B.; Ryan, D.; Higgins, A.; Foca, M.; LaRussa, P.; Gershon, A.; Scott, G. B.; Mitchell, C. D.; Taybo, L.; Gamber, C.; Petru, A.; Courville, T.; Gold, K.; Johnson, L.; Piatt, J. P.; Foti, J.; Clarke-Steffen, L.; Belho, T.; Pitkin, B.; Eddleman, J.; Bonagura, V. R.; Schuval, S. J.; Colter, C.; Abrams, E. J.; Frere, M.; Calo, D.; Champion, S.; Handelsman, E.; Moallem, H. J.; Swindell, D. M.; Kaye, J. M.; Chin, M.; Dorio, K.; Wiznia, A.; Donovan, M.; Acevedo, M.; Gonzalez, M.; Fabregas, L.; Texidor, M. E.; Andiman, W. A.; Romano, S.; Hurst, L.; De Jesus, J.; Weiner, L. B.; Contello, K. A.; Holz, W. A.; Famiglietti, M. J.; Nachman, S.; Nikolic-Djokic, D.; Ferraro, D.; Perillo, J.; Rana, S.; Finke-Castro, H.; Yu, P. H.; Roa, J. C.; Rathore, M. H.; Khayat, A.; Champion, K.; Cusic, S.; Flynn, P. M.; Knapp, K.; Patel, N.; Wilson, G.; McGann, K. A.; Pickering, L.; Storch, G. A.; Douglas, S. D.; Koutsoubis, G.; Rutstein, R. M.; Vincent, C. A.; Silio, M.; Alchediak, T.; Boe, C.; Cowie, M.; Stechenberg, B. W.; Fisher, D. J.; Johnston, A. M.; Toye, M.; Mani, Chitra S; Foshee, S.; Kiean, B.; Cobb, S.; Farley, J.; Klipner, K.

In: Pediatrics, Vol. 117, No. 2, 01.02.2006, p. 273-283.

Research output: Contribution to journalArticle

Lee, GM, Gortmaker, SL, McIntosh, K, Hughes, MD, Oleske, JM, Palumbo, P, Andrew, P, Dieudonne, A, Dashefsky, B, Gaur, S, Whitley-Williams, P, Malhotra, A, Cerracchio, L, Keller, M, Hayes, J, Gagajena, A, Mink, C, Hutton, N, Griffith, B, Joyner, M, Kiefner, C, Minglana, F, Paul, ME, Shearer, WT, Jackson, CD, Johnson, DC, Kowalski, D, Wolfe, B, Ryan, D, Higgins, A, Foca, M, LaRussa, P, Gershon, A, Scott, GB, Mitchell, CD, Taybo, L, Gamber, C, Petru, A, Courville, T, Gold, K, Johnson, L, Piatt, JP, Foti, J, Clarke-Steffen, L, Belho, T, Pitkin, B, Eddleman, J, Bonagura, VR, Schuval, SJ, Colter, C, Abrams, EJ, Frere, M, Calo, D, Champion, S, Handelsman, E, Moallem, HJ, Swindell, DM, Kaye, JM, Chin, M, Dorio, K, Wiznia, A, Donovan, M, Acevedo, M, Gonzalez, M, Fabregas, L, Texidor, ME, Andiman, WA, Romano, S, Hurst, L, De Jesus, J, Weiner, LB, Contello, KA, Holz, WA, Famiglietti, MJ, Nachman, S, Nikolic-Djokic, D, Ferraro, D, Perillo, J, Rana, S, Finke-Castro, H, Yu, PH, Roa, JC, Rathore, MH, Khayat, A, Champion, K, Cusic, S, Flynn, PM, Knapp, K, Patel, N, Wilson, G, McGann, KA, Pickering, L, Storch, GA, Douglas, SD, Koutsoubis, G, Rutstein, RM, Vincent, CA, Silio, M, Alchediak, T, Boe, C, Cowie, M, Stechenberg, BW, Fisher, DJ, Johnston, AM, Toye, M, Mani, CS, Foshee, S, Kiean, B, Cobb, S, Farley, J & Klipner, K 2006, 'Quality of life for children and adolescents: Impact of HIV infection and antiretroviral treatment', Pediatrics, vol. 117, no. 2, pp. 273-283. https://doi.org/10.1542/peds.2005-0323
Lee GM, Gortmaker SL, McIntosh K, Hughes MD, Oleske JM, Palumbo P et al. Quality of life for children and adolescents: Impact of HIV infection and antiretroviral treatment. Pediatrics. 2006 Feb 1;117(2):273-283. https://doi.org/10.1542/peds.2005-0323
Lee, Grace M. ; Gortmaker, Steven L. ; McIntosh, Kenneth ; Hughes, Michael D. ; Oleske, James M. ; Palumbo, P. ; Andrew, P. ; Dieudonne, A. ; Dashefsky, B. ; Gaur, S. ; Whitley-Williams, P. ; Malhotra, A. ; Cerracchio, L. ; Keller, M. ; Hayes, J. ; Gagajena, A. ; Mink, C. ; Hutton, N. ; Griffith, B. ; Joyner, M. ; Kiefner, C. ; Minglana, F. ; Paul, M. E. ; Shearer, W. T. ; Jackson, C. D. ; Johnson, D. C. ; Kowalski, D. ; Wolfe, B. ; Ryan, D. ; Higgins, A. ; Foca, M. ; LaRussa, P. ; Gershon, A. ; Scott, G. B. ; Mitchell, C. D. ; Taybo, L. ; Gamber, C. ; Petru, A. ; Courville, T. ; Gold, K. ; Johnson, L. ; Piatt, J. P. ; Foti, J. ; Clarke-Steffen, L. ; Belho, T. ; Pitkin, B. ; Eddleman, J. ; Bonagura, V. R. ; Schuval, S. J. ; Colter, C. ; Abrams, E. J. ; Frere, M. ; Calo, D. ; Champion, S. ; Handelsman, E. ; Moallem, H. J. ; Swindell, D. M. ; Kaye, J. M. ; Chin, M. ; Dorio, K. ; Wiznia, A. ; Donovan, M. ; Acevedo, M. ; Gonzalez, M. ; Fabregas, L. ; Texidor, M. E. ; Andiman, W. A. ; Romano, S. ; Hurst, L. ; De Jesus, J. ; Weiner, L. B. ; Contello, K. A. ; Holz, W. A. ; Famiglietti, M. J. ; Nachman, S. ; Nikolic-Djokic, D. ; Ferraro, D. ; Perillo, J. ; Rana, S. ; Finke-Castro, H. ; Yu, P. H. ; Roa, J. C. ; Rathore, M. H. ; Khayat, A. ; Champion, K. ; Cusic, S. ; Flynn, P. M. ; Knapp, K. ; Patel, N. ; Wilson, G. ; McGann, K. A. ; Pickering, L. ; Storch, G. A. ; Douglas, S. D. ; Koutsoubis, G. ; Rutstein, R. M. ; Vincent, C. A. ; Silio, M. ; Alchediak, T. ; Boe, C. ; Cowie, M. ; Stechenberg, B. W. ; Fisher, D. J. ; Johnston, A. M. ; Toye, M. ; Mani, Chitra S ; Foshee, S. ; Kiean, B. ; Cobb, S. ; Farley, J. ; Klipner, K. / Quality of life for children and adolescents : Impact of HIV infection and antiretroviral treatment. In: Pediatrics. 2006 ; Vol. 117, No. 2. pp. 273-283.
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abstract = "BACKGROUND. HIV/AIDS mortality rates in the United States are declining; pediatric HIV has become a chronic disease, with quality of life (QoL) outcomes assuming greater importance. OBJECTIVES. To compare QoL among HIV-infected and uninfected children and to assess the impact of different antiretroviral regimens on QoL among HIV-infected children. METHODS. Perinatally exposed, HIV-infected (N = 1847) and uninfected (N = 712) children and adolescents were studied. Among infected children, 1283 were available for the antiretroviral regimen analysis. QoL domain scores were assessed for subjects 6 months to 4 years, 5 to 11 years, and 12 to 21 years of age, and the impact of infection status and alternative treatment regimens on QoL domains was evaluated. RESULTS. HIV infection was associated with significantly worse mean adjusted scores for functional status among children 6 months to 4 years of age and health perceptions, physical resilience, physical functioning, and social/role functioning among those 5 to 11 years of age. However, uninfected children 5 to 11 years of age reported significantly worse psychological functioning. HIV-infected children (5-11 years of age) and adolescents (12-21 years of age) receiving no antiretroviral treatment had worse health perceptions. Adolescents receiving no antiretroviral agents also had worse symptoms. When antiretroviral regimens were compared, adolescents receiving protease inhibitor plus nonnucleoside reverse transcriptase inhibitor-containing therapy had worse symptoms, compared with those receiving protease inhibitor-containing therapy; otherwise, no significant differences were found. CONCLUSIONS. Generally parents of HIV-infected children 6 months to 4 years and 5 to 11 years of age generally reported lower mean QoL scores than did parents of uninfected children, although worse psychological functioning was reported for uninfected children. HIV-infected adolescents not receiving antiretroviral treatment had worse health perceptions and symptoms. We found no consistent QoL differences among children receiving different antiretroviral regimens.",
keywords = "Antiretroviral therapy, HIV, Quality of life",
author = "Lee, {Grace M.} and Gortmaker, {Steven L.} and Kenneth McIntosh and Hughes, {Michael D.} and Oleske, {James M.} and P. Palumbo and P. Andrew and A. Dieudonne and B. Dashefsky and S. Gaur and P. Whitley-Williams and A. Malhotra and L. Cerracchio and M. Keller and J. Hayes and A. Gagajena and C. Mink and N. Hutton and B. Griffith and M. Joyner and C. Kiefner and F. Minglana and Paul, {M. E.} and Shearer, {W. T.} and Jackson, {C. D.} and Johnson, {D. C.} and D. Kowalski and B. Wolfe and D. Ryan and A. Higgins and M. Foca and P. LaRussa and A. Gershon and Scott, {G. B.} and Mitchell, {C. D.} and L. Taybo and C. Gamber and A. Petru and T. Courville and K. Gold and L. Johnson and Piatt, {J. P.} and J. Foti and L. Clarke-Steffen and T. Belho and B. Pitkin and J. Eddleman and Bonagura, {V. R.} and Schuval, {S. J.} and C. Colter and Abrams, {E. J.} and M. Frere and D. Calo and S. Champion and E. Handelsman and Moallem, {H. J.} and Swindell, {D. M.} and Kaye, {J. M.} and M. Chin and K. Dorio and A. Wiznia and M. Donovan and M. Acevedo and M. Gonzalez and L. Fabregas and Texidor, {M. E.} and Andiman, {W. A.} and S. Romano and L. Hurst and {De Jesus}, J. and Weiner, {L. B.} and Contello, {K. A.} and Holz, {W. A.} and Famiglietti, {M. J.} and S. Nachman and D. Nikolic-Djokic and D. Ferraro and J. Perillo and S. Rana and H. Finke-Castro and Yu, {P. H.} and Roa, {J. C.} and Rathore, {M. H.} and A. Khayat and K. Champion and S. Cusic and Flynn, {P. M.} and K. Knapp and N. Patel and G. Wilson and McGann, {K. A.} and L. Pickering and Storch, {G. A.} and Douglas, {S. D.} and G. Koutsoubis and Rutstein, {R. M.} and Vincent, {C. A.} and M. Silio and T. Alchediak and C. Boe and M. Cowie and Stechenberg, {B. W.} and Fisher, {D. J.} and Johnston, {A. M.} and M. Toye and Mani, {Chitra S} and S. Foshee and B. Kiean and S. Cobb and J. Farley and K. Klipner",
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TY - JOUR

T1 - Quality of life for children and adolescents

T2 - Impact of HIV infection and antiretroviral treatment

AU - Lee, Grace M.

AU - Gortmaker, Steven L.

AU - McIntosh, Kenneth

AU - Hughes, Michael D.

AU - Oleske, James M.

AU - Palumbo, P.

AU - Andrew, P.

AU - Dieudonne, A.

AU - Dashefsky, B.

AU - Gaur, S.

AU - Whitley-Williams, P.

AU - Malhotra, A.

AU - Cerracchio, L.

AU - Keller, M.

AU - Hayes, J.

AU - Gagajena, A.

AU - Mink, C.

AU - Hutton, N.

AU - Griffith, B.

AU - Joyner, M.

AU - Kiefner, C.

AU - Minglana, F.

AU - Paul, M. E.

AU - Shearer, W. T.

AU - Jackson, C. D.

AU - Johnson, D. C.

AU - Kowalski, D.

AU - Wolfe, B.

AU - Ryan, D.

AU - Higgins, A.

AU - Foca, M.

AU - LaRussa, P.

AU - Gershon, A.

AU - Scott, G. B.

AU - Mitchell, C. D.

AU - Taybo, L.

AU - Gamber, C.

AU - Petru, A.

AU - Courville, T.

AU - Gold, K.

AU - Johnson, L.

AU - Piatt, J. P.

AU - Foti, J.

AU - Clarke-Steffen, L.

AU - Belho, T.

AU - Pitkin, B.

AU - Eddleman, J.

AU - Bonagura, V. R.

AU - Schuval, S. J.

AU - Colter, C.

AU - Abrams, E. J.

AU - Frere, M.

AU - Calo, D.

AU - Champion, S.

AU - Handelsman, E.

AU - Moallem, H. J.

AU - Swindell, D. M.

AU - Kaye, J. M.

AU - Chin, M.

AU - Dorio, K.

AU - Wiznia, A.

AU - Donovan, M.

AU - Acevedo, M.

AU - Gonzalez, M.

AU - Fabregas, L.

AU - Texidor, M. E.

AU - Andiman, W. A.

AU - Romano, S.

AU - Hurst, L.

AU - De Jesus, J.

AU - Weiner, L. B.

AU - Contello, K. A.

AU - Holz, W. A.

AU - Famiglietti, M. J.

AU - Nachman, S.

AU - Nikolic-Djokic, D.

AU - Ferraro, D.

AU - Perillo, J.

AU - Rana, S.

AU - Finke-Castro, H.

AU - Yu, P. H.

AU - Roa, J. C.

AU - Rathore, M. H.

AU - Khayat, A.

AU - Champion, K.

AU - Cusic, S.

AU - Flynn, P. M.

AU - Knapp, K.

AU - Patel, N.

AU - Wilson, G.

AU - McGann, K. A.

AU - Pickering, L.

AU - Storch, G. A.

AU - Douglas, S. D.

AU - Koutsoubis, G.

AU - Rutstein, R. M.

AU - Vincent, C. A.

AU - Silio, M.

AU - Alchediak, T.

AU - Boe, C.

AU - Cowie, M.

AU - Stechenberg, B. W.

AU - Fisher, D. J.

AU - Johnston, A. M.

AU - Toye, M.

AU - Mani, Chitra S

AU - Foshee, S.

AU - Kiean, B.

AU - Cobb, S.

AU - Farley, J.

AU - Klipner, K.

PY - 2006/2/1

Y1 - 2006/2/1

N2 - BACKGROUND. HIV/AIDS mortality rates in the United States are declining; pediatric HIV has become a chronic disease, with quality of life (QoL) outcomes assuming greater importance. OBJECTIVES. To compare QoL among HIV-infected and uninfected children and to assess the impact of different antiretroviral regimens on QoL among HIV-infected children. METHODS. Perinatally exposed, HIV-infected (N = 1847) and uninfected (N = 712) children and adolescents were studied. Among infected children, 1283 were available for the antiretroviral regimen analysis. QoL domain scores were assessed for subjects 6 months to 4 years, 5 to 11 years, and 12 to 21 years of age, and the impact of infection status and alternative treatment regimens on QoL domains was evaluated. RESULTS. HIV infection was associated with significantly worse mean adjusted scores for functional status among children 6 months to 4 years of age and health perceptions, physical resilience, physical functioning, and social/role functioning among those 5 to 11 years of age. However, uninfected children 5 to 11 years of age reported significantly worse psychological functioning. HIV-infected children (5-11 years of age) and adolescents (12-21 years of age) receiving no antiretroviral treatment had worse health perceptions. Adolescents receiving no antiretroviral agents also had worse symptoms. When antiretroviral regimens were compared, adolescents receiving protease inhibitor plus nonnucleoside reverse transcriptase inhibitor-containing therapy had worse symptoms, compared with those receiving protease inhibitor-containing therapy; otherwise, no significant differences were found. CONCLUSIONS. Generally parents of HIV-infected children 6 months to 4 years and 5 to 11 years of age generally reported lower mean QoL scores than did parents of uninfected children, although worse psychological functioning was reported for uninfected children. HIV-infected adolescents not receiving antiretroviral treatment had worse health perceptions and symptoms. We found no consistent QoL differences among children receiving different antiretroviral regimens.

AB - BACKGROUND. HIV/AIDS mortality rates in the United States are declining; pediatric HIV has become a chronic disease, with quality of life (QoL) outcomes assuming greater importance. OBJECTIVES. To compare QoL among HIV-infected and uninfected children and to assess the impact of different antiretroviral regimens on QoL among HIV-infected children. METHODS. Perinatally exposed, HIV-infected (N = 1847) and uninfected (N = 712) children and adolescents were studied. Among infected children, 1283 were available for the antiretroviral regimen analysis. QoL domain scores were assessed for subjects 6 months to 4 years, 5 to 11 years, and 12 to 21 years of age, and the impact of infection status and alternative treatment regimens on QoL domains was evaluated. RESULTS. HIV infection was associated with significantly worse mean adjusted scores for functional status among children 6 months to 4 years of age and health perceptions, physical resilience, physical functioning, and social/role functioning among those 5 to 11 years of age. However, uninfected children 5 to 11 years of age reported significantly worse psychological functioning. HIV-infected children (5-11 years of age) and adolescents (12-21 years of age) receiving no antiretroviral treatment had worse health perceptions. Adolescents receiving no antiretroviral agents also had worse symptoms. When antiretroviral regimens were compared, adolescents receiving protease inhibitor plus nonnucleoside reverse transcriptase inhibitor-containing therapy had worse symptoms, compared with those receiving protease inhibitor-containing therapy; otherwise, no significant differences were found. CONCLUSIONS. Generally parents of HIV-infected children 6 months to 4 years and 5 to 11 years of age generally reported lower mean QoL scores than did parents of uninfected children, although worse psychological functioning was reported for uninfected children. HIV-infected adolescents not receiving antiretroviral treatment had worse health perceptions and symptoms. We found no consistent QoL differences among children receiving different antiretroviral regimens.

KW - Antiretroviral therapy

KW - HIV

KW - Quality of life

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UR - http://www.scopus.com/inward/citedby.url?scp=33644868293&partnerID=8YFLogxK

U2 - 10.1542/peds.2005-0323

DO - 10.1542/peds.2005-0323

M3 - Article

VL - 117

SP - 273

EP - 283

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 2

ER -