Quality of life outcomes in laryngeal and oropharyngeal cancer patients after chemoradiation

Sarah E. Mowry, Maria M. LoTempio, Ahmad Sadeghi, Kevin H. Wang, Marilene B. Wang

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: The purpose of this study was to compare quality of life issues in patients with advanced laryngeal versus oropharyngeal cancer after treatment with chemoradiation. Design: A cohort study of 31 patients with laryngeal or oropharyngeal squamous cell carcinoma treated with chemoradiation completed the University of Washington quality of life instrument version 4 (UW-QOL v4). Statistical analysis was performed with Wilcoxon rank sum and chi-square tests. Setting: Academic tertiary care center. Results: Both groups reported similar impairment in the domains of swallowing, chewing, and taste. Oropharyngeal cancer patients reported significantly worse quality of life in the domain of saliva (P < 0.007). Conclusion: Swallowing, chewing, and taste were adversely affected by chemoradiation for both groups. Oropharyngeal patients experienced significantly worse problems with saliva than laryngeal patients. These patients reported high levels of satisfaction with health-related quality of life issues. Significance: Specific head and neck subsites have different morbidities when treated with primary chemoradiation for advanced tumors.

Original languageEnglish (US)
Pages (from-to)565-570
Number of pages6
JournalOtolaryngology - Head and Neck Surgery
Volume135
Issue number4
DOIs
StatePublished - Oct 1 2006

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Oropharyngeal Neoplasms
Laryngeal Neoplasms
Quality of Life
Mastication
Deglutition
Saliva
Chi-Square Distribution
Tertiary Care Centers
Squamous Cell Carcinoma
Cohort Studies
Neck
Head
Morbidity
Neoplasms

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Cite this

Quality of life outcomes in laryngeal and oropharyngeal cancer patients after chemoradiation. / Mowry, Sarah E.; LoTempio, Maria M.; Sadeghi, Ahmad; Wang, Kevin H.; Wang, Marilene B.

In: Otolaryngology - Head and Neck Surgery, Vol. 135, No. 4, 01.10.2006, p. 565-570.

Research output: Contribution to journalArticle

Mowry, Sarah E. ; LoTempio, Maria M. ; Sadeghi, Ahmad ; Wang, Kevin H. ; Wang, Marilene B. / Quality of life outcomes in laryngeal and oropharyngeal cancer patients after chemoradiation. In: Otolaryngology - Head and Neck Surgery. 2006 ; Vol. 135, No. 4. pp. 565-570.
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