Quantification of nerve tension after nerve repair: Correlations with nerve defects and nerve regeneration

F. Zhang, M. Inserra, L. Richards, David J Terris, W. C. Lineaweaver

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

This study tested the validity of a quantitative in vitro nerve-tension-measuring technique, by correlating the tension measurements with functional and morphologic assessments of nerve regeneration. Initially, harvested nerves were used in vitro to determine a K value for lateral displacement in this tissue. Next, this value was used to calculate the tension of nerve repair, following 0-, 3-, 6-, and 9-mm resections of nerves in groups of rats. After quantifying the nerve tensions following excision and repair, the authors determined a sciatic function index to evaluate functional recovery and axon diameter in the animals. Functional recovery was significantly impaired in animals with elevated measurable tension (9.04 ± 0.74 g in a 6-mm defect, 27.76 ± 8.86 g in a 9-mm defect), compared to animals with no or 3-mm excision and measured tension of 3.3 ± 1.09 g or less. Increased tension was also associated with a significant decrease in axon diameter. This study succeeded, therefore, in quantitatively relating the elements of measured nerve tension, nerve gaps, functional nerve recovery, and morphologic regeneration. Quantification of nerve tension by lateral displacement in vivo offers a possible solution to clinical management of nerve gaps, when the choice between primary repair and nerve grafting is not a clear one.

Original languageEnglish (US)
Pages (from-to)445-451
Number of pages7
JournalJournal of Reconstructive Microsurgery
Volume17
Issue number6
DOIs
StatePublished - Sep 3 2001
Externally publishedYes

Fingerprint

Nerve Regeneration
Axons
DNA Repair
Regeneration
In Vitro Techniques

Keywords

  • Nerve regeneration
  • Nerve repair
  • Nerve tension

ASJC Scopus subject areas

  • Surgery

Cite this

Quantification of nerve tension after nerve repair : Correlations with nerve defects and nerve regeneration. / Zhang, F.; Inserra, M.; Richards, L.; Terris, David J; Lineaweaver, W. C.

In: Journal of Reconstructive Microsurgery, Vol. 17, No. 6, 03.09.2001, p. 445-451.

Research output: Contribution to journalArticle

@article{75ecdfc0f5ee488e970089fc05c24e37,
title = "Quantification of nerve tension after nerve repair: Correlations with nerve defects and nerve regeneration",
abstract = "This study tested the validity of a quantitative in vitro nerve-tension-measuring technique, by correlating the tension measurements with functional and morphologic assessments of nerve regeneration. Initially, harvested nerves were used in vitro to determine a K value for lateral displacement in this tissue. Next, this value was used to calculate the tension of nerve repair, following 0-, 3-, 6-, and 9-mm resections of nerves in groups of rats. After quantifying the nerve tensions following excision and repair, the authors determined a sciatic function index to evaluate functional recovery and axon diameter in the animals. Functional recovery was significantly impaired in animals with elevated measurable tension (9.04 ± 0.74 g in a 6-mm defect, 27.76 ± 8.86 g in a 9-mm defect), compared to animals with no or 3-mm excision and measured tension of 3.3 ± 1.09 g or less. Increased tension was also associated with a significant decrease in axon diameter. This study succeeded, therefore, in quantitatively relating the elements of measured nerve tension, nerve gaps, functional nerve recovery, and morphologic regeneration. Quantification of nerve tension by lateral displacement in vivo offers a possible solution to clinical management of nerve gaps, when the choice between primary repair and nerve grafting is not a clear one.",
keywords = "Nerve regeneration, Nerve repair, Nerve tension",
author = "F. Zhang and M. Inserra and L. Richards and Terris, {David J} and Lineaweaver, {W. C.}",
year = "2001",
month = "9",
day = "3",
doi = "10.1055/s-2001-16360",
language = "English (US)",
volume = "17",
pages = "445--451",
journal = "Journal of Reconstructive Microsurgery",
issn = "0743-684X",
publisher = "Thieme Medical Publishers",
number = "6",

}

TY - JOUR

T1 - Quantification of nerve tension after nerve repair

T2 - Correlations with nerve defects and nerve regeneration

AU - Zhang, F.

AU - Inserra, M.

AU - Richards, L.

AU - Terris, David J

AU - Lineaweaver, W. C.

PY - 2001/9/3

Y1 - 2001/9/3

N2 - This study tested the validity of a quantitative in vitro nerve-tension-measuring technique, by correlating the tension measurements with functional and morphologic assessments of nerve regeneration. Initially, harvested nerves were used in vitro to determine a K value for lateral displacement in this tissue. Next, this value was used to calculate the tension of nerve repair, following 0-, 3-, 6-, and 9-mm resections of nerves in groups of rats. After quantifying the nerve tensions following excision and repair, the authors determined a sciatic function index to evaluate functional recovery and axon diameter in the animals. Functional recovery was significantly impaired in animals with elevated measurable tension (9.04 ± 0.74 g in a 6-mm defect, 27.76 ± 8.86 g in a 9-mm defect), compared to animals with no or 3-mm excision and measured tension of 3.3 ± 1.09 g or less. Increased tension was also associated with a significant decrease in axon diameter. This study succeeded, therefore, in quantitatively relating the elements of measured nerve tension, nerve gaps, functional nerve recovery, and morphologic regeneration. Quantification of nerve tension by lateral displacement in vivo offers a possible solution to clinical management of nerve gaps, when the choice between primary repair and nerve grafting is not a clear one.

AB - This study tested the validity of a quantitative in vitro nerve-tension-measuring technique, by correlating the tension measurements with functional and morphologic assessments of nerve regeneration. Initially, harvested nerves were used in vitro to determine a K value for lateral displacement in this tissue. Next, this value was used to calculate the tension of nerve repair, following 0-, 3-, 6-, and 9-mm resections of nerves in groups of rats. After quantifying the nerve tensions following excision and repair, the authors determined a sciatic function index to evaluate functional recovery and axon diameter in the animals. Functional recovery was significantly impaired in animals with elevated measurable tension (9.04 ± 0.74 g in a 6-mm defect, 27.76 ± 8.86 g in a 9-mm defect), compared to animals with no or 3-mm excision and measured tension of 3.3 ± 1.09 g or less. Increased tension was also associated with a significant decrease in axon diameter. This study succeeded, therefore, in quantitatively relating the elements of measured nerve tension, nerve gaps, functional nerve recovery, and morphologic regeneration. Quantification of nerve tension by lateral displacement in vivo offers a possible solution to clinical management of nerve gaps, when the choice between primary repair and nerve grafting is not a clear one.

KW - Nerve regeneration

KW - Nerve repair

KW - Nerve tension

UR - http://www.scopus.com/inward/record.url?scp=0034887586&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034887586&partnerID=8YFLogxK

U2 - 10.1055/s-2001-16360

DO - 10.1055/s-2001-16360

M3 - Article

C2 - 11507693

AN - SCOPUS:0034887586

VL - 17

SP - 445

EP - 451

JO - Journal of Reconstructive Microsurgery

JF - Journal of Reconstructive Microsurgery

SN - 0743-684X

IS - 6

ER -