Quantitative IgE antibody assays in allergic diseases

John W. Yunginger, Staffan Ahlstedt, Peyton A. Eggleston, Henry A. Homburger, Harold S. Nelson, Dennis Randall Ownby, Thomas A.E. Platts-Mills, Hugh A. Sampson, Scott H. Sicherer, Allan M. Weinstein, P. Brock Williams, Robert A. Wood, Robert S. Zeiger

Research output: Contribution to journalArticle

153 Citations (Scopus)

Abstract

During the past several years, immunoassays for specific IgE antibodies have been refined to permit reporting results in mass units. Thus quantitative immunoassays for IgE antibodies may be an adjunct to skin tests. In cases of food allergy among children with atopic dermatitis, cutoff values for IgE antibody concentrations to egg, milk, peanut, and fish have been derived to provide 95% positive and 90% negative predictive values. Food-specific IgE antibody determinations can also be used to predict which food allergies are resolving spontaneously. Elevated egg-specific IgE antibody levels in infancy are associated with significantly increased risk for development of inhalant allergies later in childhood. In cases of inhalant allergy, specific IgE antibody levels correlate closely with results of inhalation challenge studies in cat-sensitive persons. Also, mite-specific IgE antibody levels correlate significantly with the mite allergen contents of reservoir dust in the homes of mite-sensitive persons. Immunoassays for quantitation of specific IgE antibodies may be used to document aller-gen sensitization over time and to evaluate the risk of reaction on allergen exposure. However, immunoassays and skin tests are not entirely interchangeable, and neither will replace the other in appropriate circumstances.

Original languageEnglish (US)
Pages (from-to)1077-1084
Number of pages8
JournalJournal of Allergy and Clinical Immunology
Volume105
Issue number6 II
DOIs
StatePublished - Jan 1 2000

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Immunoglobulin E
Antibodies
Immunoassay
Mites
Food Hypersensitivity
Skin Tests
Allergens
Ovum
Hypersensitivity
Atopic Dermatitis
Dust
Inhalation
Fishes
Milk
Cats
Food

Keywords

  • Allergic disease
  • IgE antibody
  • Quantitative immunoassay

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Yunginger, J. W., Ahlstedt, S., Eggleston, P. A., Homburger, H. A., Nelson, H. S., Ownby, D. R., ... Zeiger, R. S. (2000). Quantitative IgE antibody assays in allergic diseases. Journal of Allergy and Clinical Immunology, 105(6 II), 1077-1084. https://doi.org/10.1067/mai.2000.107041

Quantitative IgE antibody assays in allergic diseases. / Yunginger, John W.; Ahlstedt, Staffan; Eggleston, Peyton A.; Homburger, Henry A.; Nelson, Harold S.; Ownby, Dennis Randall; Platts-Mills, Thomas A.E.; Sampson, Hugh A.; Sicherer, Scott H.; Weinstein, Allan M.; Williams, P. Brock; Wood, Robert A.; Zeiger, Robert S.

In: Journal of Allergy and Clinical Immunology, Vol. 105, No. 6 II, 01.01.2000, p. 1077-1084.

Research output: Contribution to journalArticle

Yunginger, JW, Ahlstedt, S, Eggleston, PA, Homburger, HA, Nelson, HS, Ownby, DR, Platts-Mills, TAE, Sampson, HA, Sicherer, SH, Weinstein, AM, Williams, PB, Wood, RA & Zeiger, RS 2000, 'Quantitative IgE antibody assays in allergic diseases', Journal of Allergy and Clinical Immunology, vol. 105, no. 6 II, pp. 1077-1084. https://doi.org/10.1067/mai.2000.107041
Yunginger JW, Ahlstedt S, Eggleston PA, Homburger HA, Nelson HS, Ownby DR et al. Quantitative IgE antibody assays in allergic diseases. Journal of Allergy and Clinical Immunology. 2000 Jan 1;105(6 II):1077-1084. https://doi.org/10.1067/mai.2000.107041
Yunginger, John W. ; Ahlstedt, Staffan ; Eggleston, Peyton A. ; Homburger, Henry A. ; Nelson, Harold S. ; Ownby, Dennis Randall ; Platts-Mills, Thomas A.E. ; Sampson, Hugh A. ; Sicherer, Scott H. ; Weinstein, Allan M. ; Williams, P. Brock ; Wood, Robert A. ; Zeiger, Robert S. / Quantitative IgE antibody assays in allergic diseases. In: Journal of Allergy and Clinical Immunology. 2000 ; Vol. 105, No. 6 II. pp. 1077-1084.
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