Quantitative measurement of regional cerebral blood flow with flow-sensitive alternating inversion recovery imaging

Comparison with [iodine 123]-iodoamphetamin single photon emission CT

Ali Syed Arbab, Shigeki Aoki, Keiji Toyama, Nobuhiko Miyazawa, Hiroshi Kumagai, Takako Umeda, Takao Arai, Tsutomu Araki, Hiroyuki Kabasawa, Yoshiyuki Takahashi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: Flow-sensitive alternating inversion recovery (FAIR) MR imaging is a technique for depicting cerebral perfusion without contrast enhancement. Our purpose was to determine whether quantification at FAIR imaging can be used to assess regional cerebral blood flow (rCBF) in a manner similar to [iodine 123]-iodoamphetamin (123I-IMP) single photon emission CT (SPECT). METHODS: Nine patients with internal carotid or major cerebral arterial stenosis underwent 123I-IMP SPECT and FAIR imaging (single section, different TIs, 1.5 T) at rest and after acetazolamide (Diamox) stress. FAIR and 123I-IMP rCBF values were compared and correlated. Receiver operating characteristic analysis was conducted to detect hypoperfused segments on FAIR images. RESULTS: rCBF values of normally perfused segments were 41.53 and 51.91 mL/100 g/min for pre- and post-acetazolamide 123I-IMP studies, respectively. Corresponding values for pre-and post-acetazolamide FAIR images, respectively, were 46.64 and 59.60 mL/100 g/min with a TI of 1200 milliseconds and 53.23 and 68.17 mL/100 g/min with a TI of 1400 milliseconds. 123I-IMP and FAIR results were significantly correlated, with both pre- and post-acetazolamide images. Sensitivity (86%) in detecting hypoperfused segments was significantly higher with post-acetazolamide images (TI, 1400 milliseconds), and specificity (82-85%) and accuracy (80-82%) were higher with all pre- and post-acetazolamide images (all TIs). CONCLUSIONS: The significant correlation, high specificity and accuracy in detecting hypoperfused segments, similar increases in flow on both post-acetazolamide images, and absence of the need for contrast enhancement suggest that FAIR imaging, like nuclear medicine study, is complementary to routine MR imaging in the assessment of cerebral perfusion.

Original languageEnglish (US)
Pages (from-to)381-388
Number of pages8
JournalAmerican Journal of Neuroradiology
Volume23
Issue number3
StatePublished - Apr 3 2002
Externally publishedYes

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Cerebrovascular Circulation
Acetazolamide
Regional Blood Flow
Photons
Iodine
Inosine Monophosphate
Perfusion
Nuclear Medicine
ROC Curve

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Quantitative measurement of regional cerebral blood flow with flow-sensitive alternating inversion recovery imaging : Comparison with [iodine 123]-iodoamphetamin single photon emission CT. / Arbab, Ali Syed; Aoki, Shigeki; Toyama, Keiji; Miyazawa, Nobuhiko; Kumagai, Hiroshi; Umeda, Takako; Arai, Takao; Araki, Tsutomu; Kabasawa, Hiroyuki; Takahashi, Yoshiyuki.

In: American Journal of Neuroradiology, Vol. 23, No. 3, 03.04.2002, p. 381-388.

Research output: Contribution to journalArticle

Arbab, Ali Syed ; Aoki, Shigeki ; Toyama, Keiji ; Miyazawa, Nobuhiko ; Kumagai, Hiroshi ; Umeda, Takako ; Arai, Takao ; Araki, Tsutomu ; Kabasawa, Hiroyuki ; Takahashi, Yoshiyuki. / Quantitative measurement of regional cerebral blood flow with flow-sensitive alternating inversion recovery imaging : Comparison with [iodine 123]-iodoamphetamin single photon emission CT. In: American Journal of Neuroradiology. 2002 ; Vol. 23, No. 3. pp. 381-388.
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abstract = "BACKGROUND AND PURPOSE: Flow-sensitive alternating inversion recovery (FAIR) MR imaging is a technique for depicting cerebral perfusion without contrast enhancement. Our purpose was to determine whether quantification at FAIR imaging can be used to assess regional cerebral blood flow (rCBF) in a manner similar to [iodine 123]-iodoamphetamin (123I-IMP) single photon emission CT (SPECT). METHODS: Nine patients with internal carotid or major cerebral arterial stenosis underwent 123I-IMP SPECT and FAIR imaging (single section, different TIs, 1.5 T) at rest and after acetazolamide (Diamox) stress. FAIR and 123I-IMP rCBF values were compared and correlated. Receiver operating characteristic analysis was conducted to detect hypoperfused segments on FAIR images. RESULTS: rCBF values of normally perfused segments were 41.53 and 51.91 mL/100 g/min for pre- and post-acetazolamide 123I-IMP studies, respectively. Corresponding values for pre-and post-acetazolamide FAIR images, respectively, were 46.64 and 59.60 mL/100 g/min with a TI of 1200 milliseconds and 53.23 and 68.17 mL/100 g/min with a TI of 1400 milliseconds. 123I-IMP and FAIR results were significantly correlated, with both pre- and post-acetazolamide images. Sensitivity (86{\%}) in detecting hypoperfused segments was significantly higher with post-acetazolamide images (TI, 1400 milliseconds), and specificity (82-85{\%}) and accuracy (80-82{\%}) were higher with all pre- and post-acetazolamide images (all TIs). CONCLUSIONS: The significant correlation, high specificity and accuracy in detecting hypoperfused segments, similar increases in flow on both post-acetazolamide images, and absence of the need for contrast enhancement suggest that FAIR imaging, like nuclear medicine study, is complementary to routine MR imaging in the assessment of cerebral perfusion.",
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T1 - Quantitative measurement of regional cerebral blood flow with flow-sensitive alternating inversion recovery imaging

T2 - Comparison with [iodine 123]-iodoamphetamin single photon emission CT

AU - Arbab, Ali Syed

AU - Aoki, Shigeki

AU - Toyama, Keiji

AU - Miyazawa, Nobuhiko

AU - Kumagai, Hiroshi

AU - Umeda, Takako

AU - Arai, Takao

AU - Araki, Tsutomu

AU - Kabasawa, Hiroyuki

AU - Takahashi, Yoshiyuki

PY - 2002/4/3

Y1 - 2002/4/3

N2 - BACKGROUND AND PURPOSE: Flow-sensitive alternating inversion recovery (FAIR) MR imaging is a technique for depicting cerebral perfusion without contrast enhancement. Our purpose was to determine whether quantification at FAIR imaging can be used to assess regional cerebral blood flow (rCBF) in a manner similar to [iodine 123]-iodoamphetamin (123I-IMP) single photon emission CT (SPECT). METHODS: Nine patients with internal carotid or major cerebral arterial stenosis underwent 123I-IMP SPECT and FAIR imaging (single section, different TIs, 1.5 T) at rest and after acetazolamide (Diamox) stress. FAIR and 123I-IMP rCBF values were compared and correlated. Receiver operating characteristic analysis was conducted to detect hypoperfused segments on FAIR images. RESULTS: rCBF values of normally perfused segments were 41.53 and 51.91 mL/100 g/min for pre- and post-acetazolamide 123I-IMP studies, respectively. Corresponding values for pre-and post-acetazolamide FAIR images, respectively, were 46.64 and 59.60 mL/100 g/min with a TI of 1200 milliseconds and 53.23 and 68.17 mL/100 g/min with a TI of 1400 milliseconds. 123I-IMP and FAIR results were significantly correlated, with both pre- and post-acetazolamide images. Sensitivity (86%) in detecting hypoperfused segments was significantly higher with post-acetazolamide images (TI, 1400 milliseconds), and specificity (82-85%) and accuracy (80-82%) were higher with all pre- and post-acetazolamide images (all TIs). CONCLUSIONS: The significant correlation, high specificity and accuracy in detecting hypoperfused segments, similar increases in flow on both post-acetazolamide images, and absence of the need for contrast enhancement suggest that FAIR imaging, like nuclear medicine study, is complementary to routine MR imaging in the assessment of cerebral perfusion.

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