Quaternary ammonium-based biomedical materials

State-of-the-art, toxicological aspects and antimicrobial resistance

Yang Jiao, Li na Niu, Sai Ma, Jing Li, Franklin Chi Meng Tay, Ji hua Chen

Research output: Contribution to journalReview article

51 Citations (Scopus)

Abstract

Microbial infections affect humans worldwide. Many quaternary ammonium compounds have been synthesized that are not only antibacterial, but also possess antifungal, antiviral and anti-matrix metalloproteinase capabilities. Incorporation of quaternary ammonium moieties into polymers represents one of the most promising strategies for preparation of antimicrobial biomaterials. Various polymerization techniques have been employed to prepare antimicrobial surfaces with quaternary ammonium functionalities; in particular, syntheses involving controlled radical polymerization techniques enable precise control over macromolecular structure, order and functionality. Although recent publications report exciting advances in the biomedical field, some of these technological developments have also been accompanied by potential toxicological and antimicrobial resistance challenges. Recent evidenced-based data on the biomedical applications of antimicrobial quaternary ammonium-containing biomaterials that are based on randomized human clinical trials, the golden standard in contemporary medicinal science, are included in the present review. This should help increase visibility, stimulate debates and spur conversations within a wider scientific community on the implications and plausibility for future developments of quaternary ammonium-based antimicrobial biomaterials.

Original languageEnglish (US)
Pages (from-to)53-90
Number of pages38
JournalProgress in Polymer Science
Volume71
DOIs
StatePublished - Aug 1 2017

Fingerprint

Ammonium Compounds
Biomaterials
Biocompatible Materials
polymerization
ammonium compounds
conversation
infectious diseases
Ammonium compounds
visibility
Quaternary Ammonium Compounds
Free radical polymerization
Visibility
preparation
polymers
synthesis
matrices
Matrix Metalloproteinases
Polymerization
Antiviral Agents
Polymers

Keywords

  • Antimicrobial resistance
  • Antimicrobial surfaces
  • Quaternary ammonium compounds
  • Toxicological aspects

ASJC Scopus subject areas

  • Ceramics and Composites
  • Surfaces and Interfaces
  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

Cite this

Quaternary ammonium-based biomedical materials : State-of-the-art, toxicological aspects and antimicrobial resistance. / Jiao, Yang; Niu, Li na; Ma, Sai; Li, Jing; Tay, Franklin Chi Meng; Chen, Ji hua.

In: Progress in Polymer Science, Vol. 71, 01.08.2017, p. 53-90.

Research output: Contribution to journalReview article

@article{b7939c2bffeb408d8a37c44a2f1113a4,
title = "Quaternary ammonium-based biomedical materials: State-of-the-art, toxicological aspects and antimicrobial resistance",
abstract = "Microbial infections affect humans worldwide. Many quaternary ammonium compounds have been synthesized that are not only antibacterial, but also possess antifungal, antiviral and anti-matrix metalloproteinase capabilities. Incorporation of quaternary ammonium moieties into polymers represents one of the most promising strategies for preparation of antimicrobial biomaterials. Various polymerization techniques have been employed to prepare antimicrobial surfaces with quaternary ammonium functionalities; in particular, syntheses involving controlled radical polymerization techniques enable precise control over macromolecular structure, order and functionality. Although recent publications report exciting advances in the biomedical field, some of these technological developments have also been accompanied by potential toxicological and antimicrobial resistance challenges. Recent evidenced-based data on the biomedical applications of antimicrobial quaternary ammonium-containing biomaterials that are based on randomized human clinical trials, the golden standard in contemporary medicinal science, are included in the present review. This should help increase visibility, stimulate debates and spur conversations within a wider scientific community on the implications and plausibility for future developments of quaternary ammonium-based antimicrobial biomaterials.",
keywords = "Antimicrobial resistance, Antimicrobial surfaces, Quaternary ammonium compounds, Toxicological aspects",
author = "Yang Jiao and Niu, {Li na} and Sai Ma and Jing Li and Tay, {Franklin Chi Meng} and Chen, {Ji hua}",
year = "2017",
month = "8",
day = "1",
doi = "10.1016/j.progpolymsci.2017.03.001",
language = "English (US)",
volume = "71",
pages = "53--90",
journal = "Progress in Polymer Science",
issn = "0079-6700",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Quaternary ammonium-based biomedical materials

T2 - State-of-the-art, toxicological aspects and antimicrobial resistance

AU - Jiao, Yang

AU - Niu, Li na

AU - Ma, Sai

AU - Li, Jing

AU - Tay, Franklin Chi Meng

AU - Chen, Ji hua

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Microbial infections affect humans worldwide. Many quaternary ammonium compounds have been synthesized that are not only antibacterial, but also possess antifungal, antiviral and anti-matrix metalloproteinase capabilities. Incorporation of quaternary ammonium moieties into polymers represents one of the most promising strategies for preparation of antimicrobial biomaterials. Various polymerization techniques have been employed to prepare antimicrobial surfaces with quaternary ammonium functionalities; in particular, syntheses involving controlled radical polymerization techniques enable precise control over macromolecular structure, order and functionality. Although recent publications report exciting advances in the biomedical field, some of these technological developments have also been accompanied by potential toxicological and antimicrobial resistance challenges. Recent evidenced-based data on the biomedical applications of antimicrobial quaternary ammonium-containing biomaterials that are based on randomized human clinical trials, the golden standard in contemporary medicinal science, are included in the present review. This should help increase visibility, stimulate debates and spur conversations within a wider scientific community on the implications and plausibility for future developments of quaternary ammonium-based antimicrobial biomaterials.

AB - Microbial infections affect humans worldwide. Many quaternary ammonium compounds have been synthesized that are not only antibacterial, but also possess antifungal, antiviral and anti-matrix metalloproteinase capabilities. Incorporation of quaternary ammonium moieties into polymers represents one of the most promising strategies for preparation of antimicrobial biomaterials. Various polymerization techniques have been employed to prepare antimicrobial surfaces with quaternary ammonium functionalities; in particular, syntheses involving controlled radical polymerization techniques enable precise control over macromolecular structure, order and functionality. Although recent publications report exciting advances in the biomedical field, some of these technological developments have also been accompanied by potential toxicological and antimicrobial resistance challenges. Recent evidenced-based data on the biomedical applications of antimicrobial quaternary ammonium-containing biomaterials that are based on randomized human clinical trials, the golden standard in contemporary medicinal science, are included in the present review. This should help increase visibility, stimulate debates and spur conversations within a wider scientific community on the implications and plausibility for future developments of quaternary ammonium-based antimicrobial biomaterials.

KW - Antimicrobial resistance

KW - Antimicrobial surfaces

KW - Quaternary ammonium compounds

KW - Toxicological aspects

UR - http://www.scopus.com/inward/record.url?scp=85015442371&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85015442371&partnerID=8YFLogxK

U2 - 10.1016/j.progpolymsci.2017.03.001

DO - 10.1016/j.progpolymsci.2017.03.001

M3 - Review article

VL - 71

SP - 53

EP - 90

JO - Progress in Polymer Science

JF - Progress in Polymer Science

SN - 0079-6700

ER -