Quinine bis-conjugates with quinolone antibiotics and peptides: synthesis and antimalarial bioassay

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Benzotriazole-mediated syntheses led to novel bis-conjugates of quinine with quinolone antibiotics and amino acid linkers which were successfully prepared by two alternative routes with excellent yields and retention of chirality. These bis conjugates retain in vitro antimalarial activity with IC(50) values ranging from 12 to 207 nM, similar to quinine itself.

Original languageEnglish (US)
Pages (from-to)8985-93
Number of pages9
JournalOrganic and Biomolecular Chemistry
Volume10
Issue number45
DOIs
StatePublished - Dec 7 2012

Fingerprint

bioassay
Quinine
Bioassay
antibiotics
Quinolones
Antimalarials
Biological Assay
peptides
Anti-Bacterial Agents
Peptides
Chirality
synthesis
chirality
amino acids
routes
Amino Acids
acids
benzotriazole
In Vitro Techniques

Keywords

  • Anti-Bacterial Agents
  • Antimalarials
  • Chemistry Techniques, Synthetic
  • Inhibitory Concentration 50
  • Peptide Fragments
  • Plasmodium falciparum
  • Quinine
  • Quinolones
  • Triazoles
  • Journal Article
  • Research Support, Non-U.S. Gov't

Cite this

Quinine bis-conjugates with quinolone antibiotics and peptides : synthesis and antimalarial bioassay. / Panda, Siva S.

In: Organic and Biomolecular Chemistry, Vol. 10, No. 45, 07.12.2012, p. 8985-93.

Research output: Contribution to journalArticle

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