Quinine conjugates and quinine analogues as potential antimalarial agents

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Malaria is a tropical disease, prevalent in Southeast Asia and Africa, resulting in over half a million deaths annually; efforts to develop new antimalarial agents are therefore particularly important. Quinine continues to play a role in the fight against malaria, but quinoline derivatives are more widely used. Drugs based on the quinoline scaffold include chloroquine and primaquine, which are able to act against the blood and liver stages of the parasite's life cycle. The purpose of this review is to discuss reported biologically active compounds based on either the quinine or quinoline scaffold that may have enhanced antimalarial activity. The review emphasises hybrid molecules, and covers advances made in the last five years. The review is divided into three sections: modifications to the quinine scaffold, modifications to aminoquinolines and finally metal-containing antimalarial compounds.

Original languageEnglish (US)
Pages (from-to)335-55
Number of pages21
JournalEuropean Journal of Medicinal Chemistry
Volume97
DOIs
StatePublished - Jun 5 2015

Fingerprint

Quinine
Antimalarials
Scaffolds
Malaria
Aminoquinolines
Primaquine
Southeastern Asia
Chloroquine
Life Cycle Stages
Liver
Life cycle
Parasites
Blood
Metals
Derivatives
Molecules
Pharmaceutical Preparations
quinoline

Keywords

  • Animals
  • Antimalarials
  • Humans
  • Malaria
  • Quinine
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

Cite this

Quinine conjugates and quinine analogues as potential antimalarial agents. / Panda, Siva S.

In: European Journal of Medicinal Chemistry, Vol. 97, 05.06.2015, p. 335-55.

Research output: Contribution to journalArticle

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