Radiation dose effect in locally advanced non-small cell lung cancer

Feng Ming Kong, Jing Zhao, Jingbo Wang, Corrine Faivre-Finn

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Radiation is the foundation of treatment for locally advanced non-small cell lung cancer (NSCLC), and as such, optimal radiation dose is essential for successful treatment. This article will briefly review biological considerations of radiation dose and their effect in the context of three-dimensional conformal radiation therapy (3D-CRT) including intensity modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT) for NSCLC. It will focus on literature review and discussions regarding radiation dose effect in locally advanced NSCLC including potential severe and lethal toxicities of high dose radiation given with concurrent chemotherapy. Potential new approaches for delivering safe and effective doses by individualizing treatment based on functional imaging are being applied in studies such as the PET boost trial and RTOG1106. The RTOG concept of delivering high dose radiation to the more resistant tumors with the use of isotoxic dose prescription and adaptive planning will also be discussed in detail.

Original languageEnglish (US)
Pages (from-to)336-347
Number of pages12
JournalJournal of Thoracic Disease
Volume6
Issue number4
DOIs
StatePublished - 2014

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Radiation Effects
Non-Small Cell Lung Carcinoma
Radiation
Radiotherapy
Prescriptions
Therapeutics
Drug Therapy
Neoplasms

Keywords

  • Non-small cell lung cancer (NSCLC)
  • concurrent chemotherapy
  • radiation dose

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Radiation dose effect in locally advanced non-small cell lung cancer. / Kong, Feng Ming; Zhao, Jing; Wang, Jingbo; Faivre-Finn, Corrine.

In: Journal of Thoracic Disease, Vol. 6, No. 4, 2014, p. 336-347.

Research output: Contribution to journalArticle

Kong, Feng Ming ; Zhao, Jing ; Wang, Jingbo ; Faivre-Finn, Corrine. / Radiation dose effect in locally advanced non-small cell lung cancer. In: Journal of Thoracic Disease. 2014 ; Vol. 6, No. 4. pp. 336-347.
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