Radiation Dose-Volume Effects in the Lung

Lawrence B. Marks, Soren M. Bentzen, Joseph O. Deasy, Feng Ming (Spring) Kong, Jeffrey D. Bradley, Ivan S. Vogelius, Issam El Naqa, Jessica L. Hubbs, Joos V. Lebesque, Robert D. Timmerman, Mary K. Martel, Andrew Jackson

Research output: Contribution to journalArticle

530 Scopus citations


The three-dimensional dose, volume, and outcome data for lung are reviewed in detail. The rate of symptomatic pneumonitis is related to many dosimetric parameters, and there are no evident threshold "tolerance dose-volume" levels. There are strong volume and fractionation effects.

Original languageEnglish (US)
JournalInternational Journal of Radiation Oncology Biology Physics
Issue number3 SUPPL.
StatePublished - Mar 1 2010



  • Lung injury
  • Pneumonitis
  • Radiation

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Marks, L. B., Bentzen, S. M., Deasy, J. O., Kong, F. M. S., Bradley, J. D., Vogelius, I. S., El Naqa, I., Hubbs, J. L., Lebesque, J. V., Timmerman, R. D., Martel, M. K., & Jackson, A. (2010). Radiation Dose-Volume Effects in the Lung. International Journal of Radiation Oncology Biology Physics, 76(3 SUPPL.). https://doi.org/10.1016/j.ijrobp.2009.06.091