Radical prostatectomy and the effect of close surgical margins: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database

Christine Herforth, Sean P. Stroup, Zinan Chen, Lauren E. Howard, Stephen J. Freedland, Daniel M. Moreira, Martha Kennedy Terris, William J. Aronson, Matthew R. Cooperberg, Christopher L. Amling, Christopher J. Kane

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To evaluate biochemical recurrence (BCR) patterns amongst men undergoing radical prostatectomy (RP) with specimens having negative (NSM), positive (PSM), and close surgical margins (CSM) from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort, as PSM after RP are a significant predictor of biochemical failure and possible disease progression, with CSM representing a diagnostic challenge for surgeons. Patients and Methods: Men undergoing RP between 1988 and 2015 with known final pathological margin status were evaluated. The cohort was divided into three groups based on margin status; NSM, PSM, and CSM. CSM were defined by distance of tumour ≤1 mm from the surgical margin. BCR was defined as a prostate-specific antigen (PSA) level of >0.2 ng/mL, two values at 0.2 ng/mL, or secondary treatment for an elevated PSA level. Predictors of BCR, metastases, and mortality were analysed using Cox proportional hazard models. Results: Of 5515 men in the SEARCH database, 4337 (79%) men met criteria for inclusion in the analysis. Of these, 2063 (48%) had NSM, 1902 (44%) had PSM, and 372 (8%) had CSM. On multivariable analysis, relative to NSM, men with CSM had a higher risk of BCR (hazard ratio [HR] 1.51, 95% confidence interval [CI] 1.25–1.82; P < 0.001) but a decreased risk of BCR when compared to those men with PSM (HR 2.09, 95% CI 1.86–2.36; P < 0.001). Metastases, prostate cancer-specific mortality and all-cause mortality did not differ based on margin status alone. Conclusions: Management of men with CSM is a diagnostic challenge, with a disease course that is not entirely benign. The evaluation of other known risk factors probably provides greater prognostic value for these men and may ultimately better select those who may benefit from adjuvant therapy.

Original languageEnglish (US)
Pages (from-to)592-598
Number of pages7
JournalBJU International
Volume122
Issue number4
DOIs
StatePublished - Oct 2018
Externally publishedYes

Fingerprint

Cancer Care Facilities
Prostatectomy
Databases
Recurrence
Prostate-Specific Antigen
Mortality
Confidence Intervals
Neoplasm Metastasis
Margins of Excision
Proportional Hazards Models
Disease Progression
Prostatic Neoplasms
Therapeutics

Keywords

  • biochemical recurrence
  • close margin
  • positive margin
  • prostate cancer

ASJC Scopus subject areas

  • Urology

Cite this

Herforth, C., Stroup, S. P., Chen, Z., Howard, L. E., Freedland, S. J., Moreira, D. M., ... Kane, C. J. (2018). Radical prostatectomy and the effect of close surgical margins: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database. BJU International, 122(4), 592-598. https://doi.org/10.1111/bju.14178

Radical prostatectomy and the effect of close surgical margins : results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database. / Herforth, Christine; Stroup, Sean P.; Chen, Zinan; Howard, Lauren E.; Freedland, Stephen J.; Moreira, Daniel M.; Terris, Martha Kennedy; Aronson, William J.; Cooperberg, Matthew R.; Amling, Christopher L.; Kane, Christopher J.

In: BJU International, Vol. 122, No. 4, 10.2018, p. 592-598.

Research output: Contribution to journalArticle

Herforth, C, Stroup, SP, Chen, Z, Howard, LE, Freedland, SJ, Moreira, DM, Terris, MK, Aronson, WJ, Cooperberg, MR, Amling, CL & Kane, CJ 2018, 'Radical prostatectomy and the effect of close surgical margins: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database', BJU International, vol. 122, no. 4, pp. 592-598. https://doi.org/10.1111/bju.14178
Herforth, Christine ; Stroup, Sean P. ; Chen, Zinan ; Howard, Lauren E. ; Freedland, Stephen J. ; Moreira, Daniel M. ; Terris, Martha Kennedy ; Aronson, William J. ; Cooperberg, Matthew R. ; Amling, Christopher L. ; Kane, Christopher J. / Radical prostatectomy and the effect of close surgical margins : results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database. In: BJU International. 2018 ; Vol. 122, No. 4. pp. 592-598.
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abstract = "Objective: To evaluate biochemical recurrence (BCR) patterns amongst men undergoing radical prostatectomy (RP) with specimens having negative (NSM), positive (PSM), and close surgical margins (CSM) from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort, as PSM after RP are a significant predictor of biochemical failure and possible disease progression, with CSM representing a diagnostic challenge for surgeons. Patients and Methods: Men undergoing RP between 1988 and 2015 with known final pathological margin status were evaluated. The cohort was divided into three groups based on margin status; NSM, PSM, and CSM. CSM were defined by distance of tumour ≤1 mm from the surgical margin. BCR was defined as a prostate-specific antigen (PSA) level of >0.2 ng/mL, two values at 0.2 ng/mL, or secondary treatment for an elevated PSA level. Predictors of BCR, metastases, and mortality were analysed using Cox proportional hazard models. Results: Of 5515 men in the SEARCH database, 4337 (79{\%}) men met criteria for inclusion in the analysis. Of these, 2063 (48{\%}) had NSM, 1902 (44{\%}) had PSM, and 372 (8{\%}) had CSM. On multivariable analysis, relative to NSM, men with CSM had a higher risk of BCR (hazard ratio [HR] 1.51, 95{\%} confidence interval [CI] 1.25–1.82; P < 0.001) but a decreased risk of BCR when compared to those men with PSM (HR 2.09, 95{\%} CI 1.86–2.36; P < 0.001). Metastases, prostate cancer-specific mortality and all-cause mortality did not differ based on margin status alone. Conclusions: Management of men with CSM is a diagnostic challenge, with a disease course that is not entirely benign. The evaluation of other known risk factors probably provides greater prognostic value for these men and may ultimately better select those who may benefit from adjuvant therapy.",
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AU - Herforth, Christine

AU - Stroup, Sean P.

AU - Chen, Zinan

AU - Howard, Lauren E.

AU - Freedland, Stephen J.

AU - Moreira, Daniel M.

AU - Terris, Martha Kennedy

AU - Aronson, William J.

AU - Cooperberg, Matthew R.

AU - Amling, Christopher L.

AU - Kane, Christopher J.

PY - 2018/10

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N2 - Objective: To evaluate biochemical recurrence (BCR) patterns amongst men undergoing radical prostatectomy (RP) with specimens having negative (NSM), positive (PSM), and close surgical margins (CSM) from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort, as PSM after RP are a significant predictor of biochemical failure and possible disease progression, with CSM representing a diagnostic challenge for surgeons. Patients and Methods: Men undergoing RP between 1988 and 2015 with known final pathological margin status were evaluated. The cohort was divided into three groups based on margin status; NSM, PSM, and CSM. CSM were defined by distance of tumour ≤1 mm from the surgical margin. BCR was defined as a prostate-specific antigen (PSA) level of >0.2 ng/mL, two values at 0.2 ng/mL, or secondary treatment for an elevated PSA level. Predictors of BCR, metastases, and mortality were analysed using Cox proportional hazard models. Results: Of 5515 men in the SEARCH database, 4337 (79%) men met criteria for inclusion in the analysis. Of these, 2063 (48%) had NSM, 1902 (44%) had PSM, and 372 (8%) had CSM. On multivariable analysis, relative to NSM, men with CSM had a higher risk of BCR (hazard ratio [HR] 1.51, 95% confidence interval [CI] 1.25–1.82; P < 0.001) but a decreased risk of BCR when compared to those men with PSM (HR 2.09, 95% CI 1.86–2.36; P < 0.001). Metastases, prostate cancer-specific mortality and all-cause mortality did not differ based on margin status alone. Conclusions: Management of men with CSM is a diagnostic challenge, with a disease course that is not entirely benign. The evaluation of other known risk factors probably provides greater prognostic value for these men and may ultimately better select those who may benefit from adjuvant therapy.

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