Radioimaging of implants in rats using Tc-99m-MDP

Michael Scott McCracken, Kurt Zinn, Jack E. Lemons, John A. Thompson, Dale Feldman

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Radiopharmaceutical isotopes are widely used clinically to detect tumors of osteogenic origin. One example is Technetium-99m methylene diphosphonate (Tc-99m-MDP). When viewed with a gamma camera, the concentration of the isotope (increased gamma activity) indicates an area of increased bone activity. This technology provides an opportunity to measure bone growth around implants In vivo. The purpose of this study was to measure Tc-99m-MDP activity around titanium alloy implants placed in the tibiae of rats. Some implant sites were treated with a growth factor; other sites served as controls. The hypothesis tested was that implants placed with a growth factor would have greater associated Tc-99m-MDP activity. Twelve adult male Sprague-Dawley rats were anesthetized and surgical access to the medial proximal tibiae was obtained. Titanium alloy screw implants were placed in six animals along with 65 μg of acidic fibroblast growth factor (FGF-1); the other six animals received implants only and served as controls. After five days, rats were injected with 1500 μCi of Tc-99m-MDP. After 3 hours, rats were imaged with a gamma camera. The Tc-99m-MDP intensity associated with each implant was quantified and the means for each group were compared using ANOVA. Implants treated with FGF-1 demonstrated significantly more Tc-99m-MDP activity than implants alone. This suggests that Tc-99m-MDP analysis may be a useful tool for determining bone growth around implants in laboratory animals in vivo.

Original languageEnglish (US)
Pages (from-to)372-378
Number of pages7
JournalClinical Oral Implants Research
Volume12
Issue number4
DOIs
StatePublished - Jan 1 2001

Fingerprint

Technetium Tc 99m Medronate
Technetium
Fibroblast Growth Factor 1
Gamma Cameras
Bone Development
Titanium
Tibia
Isotopes
Intercellular Signaling Peptides and Proteins
Radiopharmaceuticals
Laboratory Animals
Sprague Dawley Rats
Analysis of Variance
Technology
Bone and Bones

Keywords

  • Bone
  • Imaging
  • Implants
  • TC-99m-MDP
  • Wound healing

ASJC Scopus subject areas

  • Oral Surgery

Cite this

McCracken, M. S., Zinn, K., Lemons, J. E., Thompson, J. A., & Feldman, D. (2001). Radioimaging of implants in rats using Tc-99m-MDP. Clinical Oral Implants Research, 12(4), 372-378. https://doi.org/10.1034/j.1600-0501.2001.012004372.x

Radioimaging of implants in rats using Tc-99m-MDP. / McCracken, Michael Scott; Zinn, Kurt; Lemons, Jack E.; Thompson, John A.; Feldman, Dale.

In: Clinical Oral Implants Research, Vol. 12, No. 4, 01.01.2001, p. 372-378.

Research output: Contribution to journalArticle

McCracken, MS, Zinn, K, Lemons, JE, Thompson, JA & Feldman, D 2001, 'Radioimaging of implants in rats using Tc-99m-MDP', Clinical Oral Implants Research, vol. 12, no. 4, pp. 372-378. https://doi.org/10.1034/j.1600-0501.2001.012004372.x
McCracken, Michael Scott ; Zinn, Kurt ; Lemons, Jack E. ; Thompson, John A. ; Feldman, Dale. / Radioimaging of implants in rats using Tc-99m-MDP. In: Clinical Oral Implants Research. 2001 ; Vol. 12, No. 4. pp. 372-378.
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