Radioimmunoscintigraphy of CEA/CA 19-9 producing tumors with I-131 labeled monoclonal antibodies

Ali S. Arbab; Kiyoshi Koizumi; Guio Uchiyama; Takao Arai; Hideo Eguchi; Yoshirou Matsumoto; Kouichi Suda

doi:10.1007/BF03164981

Radioimmunoscintigraphy of CEA/CA 19-9 producing tumors with I-131 labeled monoclonal antibodies

Ali S. Arbab, Kiyoshi Koizumi, Guio Uchiyama, Takao Arai, Hideo Eguchi, Yoshirou Matsumoto, Kouichi Suda

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A total of 7 (4 males and 3 females) patients were included in this retrospective study to determine the sensitivity of radioimmunoscintigraphy with I-131 labeled anti CEA/CA 19-9 monoclonal antibodies. Out of 7 patients 2 had ascending colon cancer, one had sigmoid colon cancer, one had rectal cancer and one had adenocarcinoma in the CBD and the remaining two had metastatic tumor (one in the lungs and the other in the liver). Whole body as well as spot images showed a 72% (5/ 7) positive scan. But post operative specimen counts and imaging showed a high tumor to nontumor ratio and a good tumor to non-tumor contrast of activity of I-131 labeled monoclonal antibody. We did not find any relation between CEA/CA 19-9 levels and scan findings. A case of liver metastasis was also detected by this radioimmnoscintigraphy.

Original language	English (US)
Pages (from-to)	9-15
Number of pages	7
Journal	Annals of Nuclear Medicine
Volume	8
Issue number	1
DOIs	https://doi.org/10.1007/BF03164981
State	Published - Mar 1994
Externally published	Yes

Keywords

CA 19-9
CEA
I-131
monoclonal antibody
radioimmunoscintigraphy

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF03164981

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@article{a2893bf5b8374aa591330fdb23d4ad64,

title = "Radioimmunoscintigraphy of CEA/CA 19-9 producing tumors with I-131 labeled monoclonal antibodies",

abstract = "A total of 7 (4 males and 3 females) patients were included in this retrospective study to determine the sensitivity of radioimmunoscintigraphy with I-131 labeled anti CEA/CA 19-9 monoclonal antibodies. Out of 7 patients 2 had ascending colon cancer, one had sigmoid colon cancer, one had rectal cancer and one had adenocarcinoma in the CBD and the remaining two had metastatic tumor (one in the lungs and the other in the liver). Whole body as well as spot images showed a 72% (5/ 7) positive scan. But post operative specimen counts and imaging showed a high tumor to nontumor ratio and a good tumor to non-tumor contrast of activity of I-131 labeled monoclonal antibody. We did not find any relation between CEA/CA 19-9 levels and scan findings. A case of liver metastasis was also detected by this radioimmnoscintigraphy.",

keywords = "CA 19-9, CEA, I-131, monoclonal antibody, radioimmunoscintigraphy",

author = "Arbab, {Ali S.} and Kiyoshi Koizumi and Guio Uchiyama and Takao Arai and Hideo Eguchi and Yoshirou Matsumoto and Kouichi Suda",

year = "1994",

month = mar,

doi = "10.1007/BF03164981",

language = "English (US)",

volume = "8",

pages = "9--15",

journal = "Annals of Nuclear Medicine",

issn = "0914-7187",

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T1 - Radioimmunoscintigraphy of CEA/CA 19-9 producing tumors with I-131 labeled monoclonal antibodies

AU - Arbab, Ali S.

AU - Koizumi, Kiyoshi

AU - Uchiyama, Guio

AU - Arai, Takao

AU - Eguchi, Hideo

AU - Matsumoto, Yoshirou

AU - Suda, Kouichi

PY - 1994/3

Y1 - 1994/3

N2 - A total of 7 (4 males and 3 females) patients were included in this retrospective study to determine the sensitivity of radioimmunoscintigraphy with I-131 labeled anti CEA/CA 19-9 monoclonal antibodies. Out of 7 patients 2 had ascending colon cancer, one had sigmoid colon cancer, one had rectal cancer and one had adenocarcinoma in the CBD and the remaining two had metastatic tumor (one in the lungs and the other in the liver). Whole body as well as spot images showed a 72% (5/ 7) positive scan. But post operative specimen counts and imaging showed a high tumor to nontumor ratio and a good tumor to non-tumor contrast of activity of I-131 labeled monoclonal antibody. We did not find any relation between CEA/CA 19-9 levels and scan findings. A case of liver metastasis was also detected by this radioimmnoscintigraphy.

AB - A total of 7 (4 males and 3 females) patients were included in this retrospective study to determine the sensitivity of radioimmunoscintigraphy with I-131 labeled anti CEA/CA 19-9 monoclonal antibodies. Out of 7 patients 2 had ascending colon cancer, one had sigmoid colon cancer, one had rectal cancer and one had adenocarcinoma in the CBD and the remaining two had metastatic tumor (one in the lungs and the other in the liver). Whole body as well as spot images showed a 72% (5/ 7) positive scan. But post operative specimen counts and imaging showed a high tumor to nontumor ratio and a good tumor to non-tumor contrast of activity of I-131 labeled monoclonal antibody. We did not find any relation between CEA/CA 19-9 levels and scan findings. A case of liver metastasis was also detected by this radioimmnoscintigraphy.

KW - CA 19-9

KW - CEA

KW - I-131

KW - monoclonal antibody

KW - radioimmunoscintigraphy

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JO - Annals of Nuclear Medicine

JF - Annals of Nuclear Medicine

IS - 1

ER -

Radioimmunoscintigraphy of CEA/CA 19-9 producing tumors with I-131 labeled monoclonal antibodies

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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