Radioimmunoscintigraphy of CEA/CA 19-9 producing tumors with I-131 labeled monoclonal antibodies

Ali Syed Arbab, Kiyoshi Koizumi, Guio Uchiyama, Takao Arai, Hideo Eguchi, Yoshirou Matsumoto, Kouichi Suda

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A total of 7 (4 males and 3 females) patients were included in this retrospective study to determine the sensitivity of radioimmunoscintigraphy with I-131 labeled anti CEA/CA 19-9 monoclonal antibodies. Out of 7 patients 2 had ascending colon cancer, one had sigmoid colon cancer, one had rectal cancer and one had adenocarcinoma in the CBD and the remaining two had metastatic tumor (one in the lungs and the other in the liver). Whole body as well as spot images showed a 72% (5/ 7) positive scan. But post operative specimen counts and imaging showed a high tumor to nontumor ratio and a good tumor to non-tumor contrast of activity of I-131 labeled monoclonal antibody. We did not find any relation between CEA/CA 19-9 levels and scan findings. A case of liver metastasis was also detected by this radioimmnoscintigraphy.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalAnnals of Nuclear Medicine
Volume8
Issue number1
DOIs
StatePublished - Mar 1 1994
Externally publishedYes

Fingerprint

Radioimmunodetection
Monoclonal Antibodies
Sigmoid Neoplasms
Ascending Colon
Neoplasms
Liver
Rectal Neoplasms
Colonic Neoplasms
Adenocarcinoma
Retrospective Studies
Neoplasm Metastasis
Lung

Keywords

  • CA 19-9
  • CEA
  • I-131
  • monoclonal antibody
  • radioimmunoscintigraphy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Radioimmunoscintigraphy of CEA/CA 19-9 producing tumors with I-131 labeled monoclonal antibodies. / Arbab, Ali Syed; Koizumi, Kiyoshi; Uchiyama, Guio; Arai, Takao; Eguchi, Hideo; Matsumoto, Yoshirou; Suda, Kouichi.

In: Annals of Nuclear Medicine, Vol. 8, No. 1, 01.03.1994, p. 9-15.

Research output: Contribution to journalArticle

Arbab, Ali Syed ; Koizumi, Kiyoshi ; Uchiyama, Guio ; Arai, Takao ; Eguchi, Hideo ; Matsumoto, Yoshirou ; Suda, Kouichi. / Radioimmunoscintigraphy of CEA/CA 19-9 producing tumors with I-131 labeled monoclonal antibodies. In: Annals of Nuclear Medicine. 1994 ; Vol. 8, No. 1. pp. 9-15.
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