Radium in Wisconsin Drinking Water: An Analysis of Osteosarcoma Risk

Clare E. Guse, Anne M. Marbella, Varghese George, Peter M. Layde

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Epidemiological studies of radium dial painters have found an association between exposure to high-dose radium and bone cancers. However, only limited data exist on the relationship between low doses of radium, as are found in some drinking water sources, and osteosarcoma. The authors conducted a population-based case-control study to examine the association between exposure to radium in drinking water and the occurrence of osteosarcoma. Estimates of radium exposure and covariates used were based on subjects' residential ZIP codes. The median radium level was not significantly associated with osteosarcoma (odds ratio =.98; 95% confidence interval =.93,1.04; p =.56). The authors found no evidence that radium, at current levels in Wisconsin drinking water, resulted in excess cases of osteosarcoma.

Original languageEnglish (US)
Pages (from-to)294-303
Number of pages10
JournalArchives of Environmental Health
Issue number4
StatePublished - Jul 1 2002
Externally publishedYes


  • Drinking water
  • Osteosarcoma
  • Radium

ASJC Scopus subject areas

  • Environmental Chemistry
  • Environmental Science(all)
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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