RAGE and its ligands in bone metabolism

Zheng Zhou, Wencheng Xiong

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The receptor for advanced glycation end products (RAGE), a member of the immunoglobulin super-family transmembrane proteins, has multiple ligands, thus, is implicated in the pathogenesis of various diseases, including diabetic complications, neurodegenerative disorders, and inflammatory responses. Its function in normal physiology is beginning to be defined, and recent studies have pointed to an important role for RAGE and its ligands [e.g., HMGB1 (high mobility group box 1)] in innate immune response. In addition, RAGE and its ligands are also implicated in osteoclast activation and bone remodeling. Understanding how RAGE and its ligands regulate bone remodeling may provide insight into the pathogenesis of diabetes and chronic inflammation associated bone loss. Recent progress relevant to the functions of RAGE and its ligands in bone remodeling is discussed in this review.

Original languageEnglish (US)
Pages (from-to)768-776
Number of pages9
JournalFrontiers in Bioscience - Scholar
Volume3 S
Issue number2
StatePublished - Jan 1 2011

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Metabolism
Bone
Bone Remodeling
Ligands
Bone and Bones
Osteitis
Physiology
Osteoclasts
Diabetes Complications
Medical problems
Innate Immunity
Neurodegenerative Diseases
Immunoglobulins
Chemical activation
Advanced Glycosylation End Product-Specific Receptor
Proteins

Keywords

  • AGE
  • Bone
  • HMGB1
  • Osteoblast
  • Osteoclasts
  • RAGE

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Zhou, Z., & Xiong, W. (2011). RAGE and its ligands in bone metabolism. Frontiers in Bioscience - Scholar, 3 S(2), 768-776.

RAGE and its ligands in bone metabolism. / Zhou, Zheng; Xiong, Wencheng.

In: Frontiers in Bioscience - Scholar, Vol. 3 S, No. 2, 01.01.2011, p. 768-776.

Research output: Contribution to journalArticle

Zhou, Z & Xiong, W 2011, 'RAGE and its ligands in bone metabolism', Frontiers in Bioscience - Scholar, vol. 3 S, no. 2, pp. 768-776.
Zhou, Zheng ; Xiong, Wencheng. / RAGE and its ligands in bone metabolism. In: Frontiers in Bioscience - Scholar. 2011 ; Vol. 3 S, No. 2. pp. 768-776.
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