TY - JOUR
T1 - Randomized trial comparing vaccinia on the external surfaces of 3 conventional bandages applied to smallpox vaccination sites in primary vaccinees
AU - Waibel, Kirk H.
AU - Ager, Edward P.
AU - Topolski, Richard L.
AU - Walsh, Douglas S.
PY - 2004/10/1
Y1 - 2004/10/1
N2 - Background. Concern about accidental contact transmission after smallpox vaccination has prompted various recommendations regarding vaccination site coverage. Methods. On days 6-8 after their first-ever smallpox vaccination, 63 adult subjects were randomized to apply a self-adhesive bandage (n = 20), gauze with adhesive tape (n = 21), or gauze with a semipermeable dressing (n = 22) over the vaccination site for a mean of 8 ± 2 h. Swabs from the external bandage surfaces and the vaccination sites were then assessed by real time vaccinia-specific polymerase chain reaction (PCR) in blinded fashion. Results. Among 58 subjects completing the study, PCR results were positive for the vaccination site in 55 (94.8%) and on 10 swabs (17.2%) from external bandage surfaces. There were no differences among the 3 bandages (P = .57). Conclusions. At 7 days after smallpox vaccination, a peak time for vaccinia shedding, a self-adhesive bandage was as effective as 2 bulkier, less convenient bandages in limiting PCR-detectable virus on the external surface.
AB - Background. Concern about accidental contact transmission after smallpox vaccination has prompted various recommendations regarding vaccination site coverage. Methods. On days 6-8 after their first-ever smallpox vaccination, 63 adult subjects were randomized to apply a self-adhesive bandage (n = 20), gauze with adhesive tape (n = 21), or gauze with a semipermeable dressing (n = 22) over the vaccination site for a mean of 8 ± 2 h. Swabs from the external bandage surfaces and the vaccination sites were then assessed by real time vaccinia-specific polymerase chain reaction (PCR) in blinded fashion. Results. Among 58 subjects completing the study, PCR results were positive for the vaccination site in 55 (94.8%) and on 10 swabs (17.2%) from external bandage surfaces. There were no differences among the 3 bandages (P = .57). Conclusions. At 7 days after smallpox vaccination, a peak time for vaccinia shedding, a self-adhesive bandage was as effective as 2 bulkier, less convenient bandages in limiting PCR-detectable virus on the external surface.
UR - http://www.scopus.com/inward/record.url?scp=4744352079&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4744352079&partnerID=8YFLogxK
U2 - 10.1086/423967
DO - 10.1086/423967
M3 - Article
C2 - 15472853
AN - SCOPUS:4744352079
SN - 1058-4838
VL - 39
SP - 1004
EP - 1007
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 7
ER -