Rapid Communication: GM3 Regulates Protein Kinase Systems in Cultured Brain Microvascular Endothelial Cells

Takashi Kanda, Toshio Ariga, Masanaga Yamawaki, Robert K. Yu

Research output: Contribution to journalArticle

10 Scopus citations


Abstract: The barrier function of endothelial cells is known to be positively regulated by protein kinase A (PKA) and negatively regulated by protein kinase C (PKC). We found that exogenously administered GM3(NeuAc) promoted PKA activity in cultured brain microvascular endothelial cells (BMECs). Other glycolipids, including GM1, sulfoglucuronyl paragloboside, and GM3(NeuGc), did not have any effect on the PKA activity of BMECs. PC12 cells did not respond to exogenously applied GM3(NeuAc). GM3(NeuAc) also suppressed the PKC activity of BMECs. Thus, GM3(NeuAc) may function as a modulator of blood‐brain barrier function via the two different kinase systems.

Original languageEnglish (US)
Pages (from-to)1969-1972
Number of pages4
JournalJournal of Neurochemistry
Issue number5
Publication statusPublished - Nov 1993
Externally publishedYes



  • GM
  • lood‐brain barrie
  • lood‐nerve barrie
  • rain endothelial cell
  • rotein kinase
  • rotein kinase

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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