TY - JOUR
T1 - Rapid hypotensive response to fasting in spontaneously hypertensive rats
AU - Fitzgerald, Sharyn M.
AU - Hall, John E.
AU - Brands, Michael W.
N1 - Funding Information:
This research was supported by Heart, Lung and Blood Institute Grants HL 56259, HL 51971, and an Established Investigator Grant from the American Heart Association (AHA) and Genentech to Dr. Brands. Dr. Fitzgerald is the recipient of a Postdoctoral Fellowship award from the Mississippi Affiliate of the AHA Southern Research Consortium.
PY - 2001
Y1 - 2001
N2 - This study examined changes in renal function and mean arterial pressure (MAP) in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats during 48 h of fasting, independent of changes in sodium intake. Spontaneously hypertensive rats (n = 17) and WKY rats (n = 10) were instrumented with artery and vein catheters and sodium intake was clamped at 2.1 mEq/day. By day 2 of fasting, MAP decreased -10 ± 1 mm Hg (P < .001) in SHR, but did not change significantly in WKY rats. Heart rate decreased significantly in both groups by day 2 of fasting and there was a significant increase in urine volume and sodium excretion. Thus, fasting caused a rapid decrease in MAP in SHR that was not due to decreased sodium intake, but may be related, in part, to volume loss and improved renal excretory function.
AB - This study examined changes in renal function and mean arterial pressure (MAP) in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats during 48 h of fasting, independent of changes in sodium intake. Spontaneously hypertensive rats (n = 17) and WKY rats (n = 10) were instrumented with artery and vein catheters and sodium intake was clamped at 2.1 mEq/day. By day 2 of fasting, MAP decreased -10 ± 1 mm Hg (P < .001) in SHR, but did not change significantly in WKY rats. Heart rate decreased significantly in both groups by day 2 of fasting and there was a significant increase in urine volume and sodium excretion. Thus, fasting caused a rapid decrease in MAP in SHR that was not due to decreased sodium intake, but may be related, in part, to volume loss and improved renal excretory function.
KW - Arterial pressure
KW - Fasting
KW - Sodium intake
KW - Spontaneously hypertensive rats
KW - Sympathetic nervous system
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U2 - 10.1016/S0895-7061(01)02209-9
DO - 10.1016/S0895-7061(01)02209-9
M3 - Article
C2 - 11724211
AN - SCOPUS:0034761241
SN - 0895-7061
VL - 14
SP - 1123
EP - 1127
JO - American journal of hypertension
JF - American journal of hypertension
IS - 11 I
ER -