Rates and Risk Factors for Condition-Specific Hospitalizations in HIV-Infected and Uninfected Women

Lytt I. Gardner, Robert S. Klein, Lynda A. Szczech, Ruby M. Phelps, Karen Tashima, Anne M. Rompalo, Paula Schuman, Ramses F Sadek, Tony C. Tong, Alan Greenberg, Scott D. Holmberg

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background: The rates and risk factors for overall and medical condition-specific hospitalizations in HIV-positive women have not been examined in detail or compared with rates in risk factor-matched HIV-negative women. Objective: To determine the rates and risk factors for overall and condition-specific hospitalizations. Methods: Prospective cohort study of 885 HIV-positive women and 425 HIV-negative women followed for semiannual research visits between 1993 and 2000 in 4 urban locations in the United States. Outcome measures were hospitalization diagnoses with diabetes mellitus, nonacute renal conditions, cardiovascular conditions, liver conditions, AIDS defining conditions, and overall hospitalizations. Clinical and laboratory risk factors were assessed at research visits every 6 months, and effects of risk factors on hospitalization rates were calculated using generalized estimating equations and Poisson regression. Results: Renal laboratory abnormalities, hypertension, and clinical AIDS were each associated with 3 of the 5 condition-specific hospitalization rates. Over time, diabetes-, nonacute renal-, and cardiovascular-related rates were flat or slightly increased and liver-related rates were significantly increased in HIV-positive women. Hospitalization rates with an AIDS-defining condition declined sharply in the latter half of the study period. Conclusions: In this population of largely African-American, inner-city, HIV-infected women, renal abnormalities, hypertension, and hepatitis C virus infection were common. Rate ratios indicated that "non-AIDS" risk factors were important predictors of hospitalization. In the highly active antiretroviral therapy era, clinicians must pay attention to these risk factors for morbidity and should closely monitor renal abnormalities, hypertension, and hepatitis status.

Original languageEnglish (US)
Pages (from-to)320-330
Number of pages11
JournalJournal of Acquired Immune Deficiency Syndromes
Volume34
Issue number3
DOIs
StatePublished - Nov 1 2003
Externally publishedYes

Fingerprint

Hospitalization
HIV
Acquired Immunodeficiency Syndrome
Renal Hypertension
Kidney
Liver
Highly Active Antiretroviral Therapy
Virus Diseases
Research
Hepacivirus
African Americans
Hepatitis
Diabetes Mellitus
Cohort Studies
Outcome Assessment (Health Care)
Prospective Studies
Hypertension
Morbidity
Population

Keywords

  • HIV
  • Hospitalization rates
  • Hospitalization risk factors
  • Renal abnormalities
  • Women

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Gardner, L. I., Klein, R. S., Szczech, L. A., Phelps, R. M., Tashima, K., Rompalo, A. M., ... Holmberg, S. D. (2003). Rates and Risk Factors for Condition-Specific Hospitalizations in HIV-Infected and Uninfected Women. Journal of Acquired Immune Deficiency Syndromes, 34(3), 320-330. https://doi.org/10.1097/00126334-200311010-00011

Rates and Risk Factors for Condition-Specific Hospitalizations in HIV-Infected and Uninfected Women. / Gardner, Lytt I.; Klein, Robert S.; Szczech, Lynda A.; Phelps, Ruby M.; Tashima, Karen; Rompalo, Anne M.; Schuman, Paula; Sadek, Ramses F; Tong, Tony C.; Greenberg, Alan; Holmberg, Scott D.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 34, No. 3, 01.11.2003, p. 320-330.

Research output: Contribution to journalArticle

Gardner, LI, Klein, RS, Szczech, LA, Phelps, RM, Tashima, K, Rompalo, AM, Schuman, P, Sadek, RF, Tong, TC, Greenberg, A & Holmberg, SD 2003, 'Rates and Risk Factors for Condition-Specific Hospitalizations in HIV-Infected and Uninfected Women', Journal of Acquired Immune Deficiency Syndromes, vol. 34, no. 3, pp. 320-330. https://doi.org/10.1097/00126334-200311010-00011
Gardner, Lytt I. ; Klein, Robert S. ; Szczech, Lynda A. ; Phelps, Ruby M. ; Tashima, Karen ; Rompalo, Anne M. ; Schuman, Paula ; Sadek, Ramses F ; Tong, Tony C. ; Greenberg, Alan ; Holmberg, Scott D. / Rates and Risk Factors for Condition-Specific Hospitalizations in HIV-Infected and Uninfected Women. In: Journal of Acquired Immune Deficiency Syndromes. 2003 ; Vol. 34, No. 3. pp. 320-330.
@article{cce7f753e07b47f8b8a422dbbb5ad72a,
title = "Rates and Risk Factors for Condition-Specific Hospitalizations in HIV-Infected and Uninfected Women",
abstract = "Background: The rates and risk factors for overall and medical condition-specific hospitalizations in HIV-positive women have not been examined in detail or compared with rates in risk factor-matched HIV-negative women. Objective: To determine the rates and risk factors for overall and condition-specific hospitalizations. Methods: Prospective cohort study of 885 HIV-positive women and 425 HIV-negative women followed for semiannual research visits between 1993 and 2000 in 4 urban locations in the United States. Outcome measures were hospitalization diagnoses with diabetes mellitus, nonacute renal conditions, cardiovascular conditions, liver conditions, AIDS defining conditions, and overall hospitalizations. Clinical and laboratory risk factors were assessed at research visits every 6 months, and effects of risk factors on hospitalization rates were calculated using generalized estimating equations and Poisson regression. Results: Renal laboratory abnormalities, hypertension, and clinical AIDS were each associated with 3 of the 5 condition-specific hospitalization rates. Over time, diabetes-, nonacute renal-, and cardiovascular-related rates were flat or slightly increased and liver-related rates were significantly increased in HIV-positive women. Hospitalization rates with an AIDS-defining condition declined sharply in the latter half of the study period. Conclusions: In this population of largely African-American, inner-city, HIV-infected women, renal abnormalities, hypertension, and hepatitis C virus infection were common. Rate ratios indicated that {"}non-AIDS{"} risk factors were important predictors of hospitalization. In the highly active antiretroviral therapy era, clinicians must pay attention to these risk factors for morbidity and should closely monitor renal abnormalities, hypertension, and hepatitis status.",
keywords = "HIV, Hospitalization rates, Hospitalization risk factors, Renal abnormalities, Women",
author = "Gardner, {Lytt I.} and Klein, {Robert S.} and Szczech, {Lynda A.} and Phelps, {Ruby M.} and Karen Tashima and Rompalo, {Anne M.} and Paula Schuman and Sadek, {Ramses F} and Tong, {Tony C.} and Alan Greenberg and Holmberg, {Scott D.}",
year = "2003",
month = "11",
day = "1",
doi = "10.1097/00126334-200311010-00011",
language = "English (US)",
volume = "34",
pages = "320--330",
journal = "Journal of Acquired Immune Deficiency Syndromes",
issn = "1525-4135",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Rates and Risk Factors for Condition-Specific Hospitalizations in HIV-Infected and Uninfected Women

AU - Gardner, Lytt I.

AU - Klein, Robert S.

AU - Szczech, Lynda A.

AU - Phelps, Ruby M.

AU - Tashima, Karen

AU - Rompalo, Anne M.

AU - Schuman, Paula

AU - Sadek, Ramses F

AU - Tong, Tony C.

AU - Greenberg, Alan

AU - Holmberg, Scott D.

PY - 2003/11/1

Y1 - 2003/11/1

N2 - Background: The rates and risk factors for overall and medical condition-specific hospitalizations in HIV-positive women have not been examined in detail or compared with rates in risk factor-matched HIV-negative women. Objective: To determine the rates and risk factors for overall and condition-specific hospitalizations. Methods: Prospective cohort study of 885 HIV-positive women and 425 HIV-negative women followed for semiannual research visits between 1993 and 2000 in 4 urban locations in the United States. Outcome measures were hospitalization diagnoses with diabetes mellitus, nonacute renal conditions, cardiovascular conditions, liver conditions, AIDS defining conditions, and overall hospitalizations. Clinical and laboratory risk factors were assessed at research visits every 6 months, and effects of risk factors on hospitalization rates were calculated using generalized estimating equations and Poisson regression. Results: Renal laboratory abnormalities, hypertension, and clinical AIDS were each associated with 3 of the 5 condition-specific hospitalization rates. Over time, diabetes-, nonacute renal-, and cardiovascular-related rates were flat or slightly increased and liver-related rates were significantly increased in HIV-positive women. Hospitalization rates with an AIDS-defining condition declined sharply in the latter half of the study period. Conclusions: In this population of largely African-American, inner-city, HIV-infected women, renal abnormalities, hypertension, and hepatitis C virus infection were common. Rate ratios indicated that "non-AIDS" risk factors were important predictors of hospitalization. In the highly active antiretroviral therapy era, clinicians must pay attention to these risk factors for morbidity and should closely monitor renal abnormalities, hypertension, and hepatitis status.

AB - Background: The rates and risk factors for overall and medical condition-specific hospitalizations in HIV-positive women have not been examined in detail or compared with rates in risk factor-matched HIV-negative women. Objective: To determine the rates and risk factors for overall and condition-specific hospitalizations. Methods: Prospective cohort study of 885 HIV-positive women and 425 HIV-negative women followed for semiannual research visits between 1993 and 2000 in 4 urban locations in the United States. Outcome measures were hospitalization diagnoses with diabetes mellitus, nonacute renal conditions, cardiovascular conditions, liver conditions, AIDS defining conditions, and overall hospitalizations. Clinical and laboratory risk factors were assessed at research visits every 6 months, and effects of risk factors on hospitalization rates were calculated using generalized estimating equations and Poisson regression. Results: Renal laboratory abnormalities, hypertension, and clinical AIDS were each associated with 3 of the 5 condition-specific hospitalization rates. Over time, diabetes-, nonacute renal-, and cardiovascular-related rates were flat or slightly increased and liver-related rates were significantly increased in HIV-positive women. Hospitalization rates with an AIDS-defining condition declined sharply in the latter half of the study period. Conclusions: In this population of largely African-American, inner-city, HIV-infected women, renal abnormalities, hypertension, and hepatitis C virus infection were common. Rate ratios indicated that "non-AIDS" risk factors were important predictors of hospitalization. In the highly active antiretroviral therapy era, clinicians must pay attention to these risk factors for morbidity and should closely monitor renal abnormalities, hypertension, and hepatitis status.

KW - HIV

KW - Hospitalization rates

KW - Hospitalization risk factors

KW - Renal abnormalities

KW - Women

UR - http://www.scopus.com/inward/record.url?scp=0242413241&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242413241&partnerID=8YFLogxK

U2 - 10.1097/00126334-200311010-00011

DO - 10.1097/00126334-200311010-00011

M3 - Article

C2 - 14600579

AN - SCOPUS:0242413241

VL - 34

SP - 320

EP - 330

JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

SN - 1525-4135

IS - 3

ER -