Abstract
Objective: Schizophrenia is associated with increased infectious disease comorbidity and mortality. Individuals with schizophrenia have increased risk of infectious hepatitis, potentially due to substance use comorbidity, sexual behaviors, and immunologic factors. We performed a systematic review and meta-analysis of the association between schizophrenia and hepatitis B and C. Method: We searched major electronic databases from inception until January 2019 for prevalence and case-control studies of infectious hepatitis in patients with schizophrenia. Random effects meta-analyses calculating odds ratios (ORs) and 95% confidence intervals (CIs) for case-controls studies, prevalence and 95% CIs, and meta-regression analyses were performed. Results: Twenty-one studies met the inclusion criteria. In case-control studies, there was an over 3-fold increased odds of hepatitis C in patients with schizophrenia (OR = 3.29, 95% CI 1.50–7.23, p = 0.003), and a prevalence of 6% (ES = 0.06, 95% CI 0.04–0.08). In case-control studies, there was an over 2-fold increased odds of hepatitis B in patients with schizophrenia (OR = 2.36, 95% CI 1.61–3.47, p < 0.001) and a prevalence of 7% (ES = 0.07, 95% CI 0.03–0.11). Conclusion: We found an approximately 3-fold increased odds of hepatitis B and C in patients with schizophrenia. This association may be due to an increased prevalence of environmental risk factors, increased susceptibility to infections, or both. Findings suggest that screening for infectious hepatitis may be germane to the clinical care of patients with schizophrenia and relevant risk factors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 41-46 |
| Number of pages | 6 |
| Journal | General Hospital Psychiatry |
| Volume | 61 |
| DOIs | |
| State | Published - Nov 1 2019 |
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Keywords
- Hepatitis
- Infection
- Meta-analysis
- Psychosis
- Schizophrenia
ASJC Scopus subject areas
- Psychiatry and Mental health
Cite this
Rates of hepatitis B and C in patients with schizophrenia : A meta-analysis. / Lluch, Emily; Miller, Brian J.
In: General Hospital Psychiatry, Vol. 61, 01.11.2019, p. 41-46.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Rates of hepatitis B and C in patients with schizophrenia
T2 - A meta-analysis
AU - Lluch, Emily
AU - Miller, Brian J.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Objective: Schizophrenia is associated with increased infectious disease comorbidity and mortality. Individuals with schizophrenia have increased risk of infectious hepatitis, potentially due to substance use comorbidity, sexual behaviors, and immunologic factors. We performed a systematic review and meta-analysis of the association between schizophrenia and hepatitis B and C. Method: We searched major electronic databases from inception until January 2019 for prevalence and case-control studies of infectious hepatitis in patients with schizophrenia. Random effects meta-analyses calculating odds ratios (ORs) and 95% confidence intervals (CIs) for case-controls studies, prevalence and 95% CIs, and meta-regression analyses were performed. Results: Twenty-one studies met the inclusion criteria. In case-control studies, there was an over 3-fold increased odds of hepatitis C in patients with schizophrenia (OR = 3.29, 95% CI 1.50–7.23, p = 0.003), and a prevalence of 6% (ES = 0.06, 95% CI 0.04–0.08). In case-control studies, there was an over 2-fold increased odds of hepatitis B in patients with schizophrenia (OR = 2.36, 95% CI 1.61–3.47, p < 0.001) and a prevalence of 7% (ES = 0.07, 95% CI 0.03–0.11). Conclusion: We found an approximately 3-fold increased odds of hepatitis B and C in patients with schizophrenia. This association may be due to an increased prevalence of environmental risk factors, increased susceptibility to infections, or both. Findings suggest that screening for infectious hepatitis may be germane to the clinical care of patients with schizophrenia and relevant risk factors.
AB - Objective: Schizophrenia is associated with increased infectious disease comorbidity and mortality. Individuals with schizophrenia have increased risk of infectious hepatitis, potentially due to substance use comorbidity, sexual behaviors, and immunologic factors. We performed a systematic review and meta-analysis of the association between schizophrenia and hepatitis B and C. Method: We searched major electronic databases from inception until January 2019 for prevalence and case-control studies of infectious hepatitis in patients with schizophrenia. Random effects meta-analyses calculating odds ratios (ORs) and 95% confidence intervals (CIs) for case-controls studies, prevalence and 95% CIs, and meta-regression analyses were performed. Results: Twenty-one studies met the inclusion criteria. In case-control studies, there was an over 3-fold increased odds of hepatitis C in patients with schizophrenia (OR = 3.29, 95% CI 1.50–7.23, p = 0.003), and a prevalence of 6% (ES = 0.06, 95% CI 0.04–0.08). In case-control studies, there was an over 2-fold increased odds of hepatitis B in patients with schizophrenia (OR = 2.36, 95% CI 1.61–3.47, p < 0.001) and a prevalence of 7% (ES = 0.07, 95% CI 0.03–0.11). Conclusion: We found an approximately 3-fold increased odds of hepatitis B and C in patients with schizophrenia. This association may be due to an increased prevalence of environmental risk factors, increased susceptibility to infections, or both. Findings suggest that screening for infectious hepatitis may be germane to the clinical care of patients with schizophrenia and relevant risk factors.
KW - Hepatitis
KW - Infection
KW - Meta-analysis
KW - Psychosis
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=85074474587&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85074474587&partnerID=8YFLogxK
U2 - 10.1016/j.genhosppsych.2019.10.007
DO - 10.1016/j.genhosppsych.2019.10.007
M3 - Review article
C2 - 31710857
AN - SCOPUS:85074474587
VL - 61
SP - 41
EP - 46
JO - General Hospital Psychiatry
JF - General Hospital Psychiatry
SN - 0163-8343
ER -