Reactive oxygen and nitrogen species in the development of pulmonary hypertension

David J Fulton, Xueyi Li, Zsuzsanna Bordan, Stephen Haigh, Austin Bentley, Feng Chen, Scott A Barman

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Pulmonary arterial hypertension (PAH) is a progressive disease of the lung vasculature that involves the loss of endothelial function together with inappropriate smooth muscle cell growth, inflammation, and fibrosis. These changes underlie a progressive remodeling of blood vessels that alters flow and increases pulmonary blood pressure. Elevated pressures in the pulmonary artery imparts a chronic stress on the right ventricle which undergoes compensatory hypertrophy but eventually fails. How PAH develops remains incompletely understood and evidence for the altered production of reactive oxygen and nitrogen species (ROS, RNS respectively) in the pulmonary circulation has been well documented. There are many different types of ROS and RNS, multiple sources, and collective actions and interactions. This review summarizes past and current knowledge of the sources of ROS and RNS and how they may contribute to the loss of endothelial function and changes in smooth muscle proliferation in the pulmonary circulation.

Original languageEnglish (US)
Article number54
JournalAntioxidants
Volume6
Issue number3
DOIs
StatePublished - Sep 1 2017

Fingerprint

Reactive Nitrogen Species
Pulmonary Circulation
Pulmonary Hypertension
Muscle
Reactive Oxygen Species
Blood pressure
Blood vessels
Cell growth
Hypertrophy
Pulmonary Artery
Lung Diseases
Heart Ventricles
Smooth Muscle Myocytes
Smooth Muscle
Blood Vessels
Fibrosis
Blood Pressure
Inflammation
Pressure
Lung

Keywords

  • Endothelial nitric oxide synthase (eNOS)
  • Nicotinamide adenine dinucleotide phosphate-oxidase (NADPH oxidase)
  • Nitric oxide
  • Nox
  • Pulmonary hypertension
  • Reactive oxygen species

ASJC Scopus subject areas

  • Physiology
  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Reactive oxygen and nitrogen species in the development of pulmonary hypertension. / Fulton, David J; Li, Xueyi; Bordan, Zsuzsanna; Haigh, Stephen; Bentley, Austin; Chen, Feng; Barman, Scott A.

In: Antioxidants, Vol. 6, No. 3, 54, 01.09.2017.

Research output: Contribution to journalReview article

Fulton, David J ; Li, Xueyi ; Bordan, Zsuzsanna ; Haigh, Stephen ; Bentley, Austin ; Chen, Feng ; Barman, Scott A. / Reactive oxygen and nitrogen species in the development of pulmonary hypertension. In: Antioxidants. 2017 ; Vol. 6, No. 3.
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