Reactive oxygen species-dependent RhoA activation mediates collagen synthesis in hyperoxic lung fibrosis

Medicine & Life Sciences

• Reactive Oxygen Species 84%
• Collagen 80%
• Fibrosis 78%
• Lung 56%
• Hyperoxia 56%
• Fibroblasts 39%
• Guanine Nucleotide Dissociation Inhibitors 35%
• Oxygen 32%
• 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt 24%
• Y 27632 10%
• rho-Associated Kinases 9%
• Pulmonary Fibrosis 8%
• Extracellular Matrix Proteins 8%
• Lung Injury 7%
• Transferases 7%
• Small Interfering RNA 6%
• Animal Models 5%
• Cell Proliferation 4%

Chemical Compounds

• Collagen 100%
• Dioxygen 50%
• Tiron 38%
• Guanine 38%
• Reactive Oxygen Metabolite 24%
• Rho Kinase Inhibitor 24%
• Silencing RNA 17%
• Protein 5%