Abstract
Reactive oxygen species (ROS) derived from both nicotinamide adenine dinucleotide phosphate oxidase (NOX) and mitochondria play a critical role in many physiological and pathological processes. However, how highly diffusible ROS produced from different sources can coordinate to drive angiogenesis and other responses is poorly understood. Recently, the cross-talk between NOX and mitochondria, termed “ROS-induced ROS release (RIRR)" has been proposed as a mechanism for ROS amplification and localized ROS production. NOX-derived ROS increase mitochondrial ROS while mitochondrial ROS stimulate NOX activation. This RIRR mechanism may represent a feed-forward vicious cycle of ROS production, which can be targeted under conditions of oxidative stress or enhanced in physiological condition. In this chapter, we will summarize the recent knowledge regarding the RIRR involved in vascular signaling and disease especially focusing on angiogenesis.
Original language | English (US) |
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Title of host publication | Endothelial Signaling in Vascular Dysfunction and Disease |
Subtitle of host publication | From Bench to Bedside |
Publisher | Elsevier |
Pages | 17-27 |
Number of pages | 11 |
ISBN (Electronic) | 9780128161968 |
DOIs | |
State | Published - Jan 1 2021 |
Keywords
- Angiogenesis
- Endothelial cell
- Reactive oxygen species
- Redox signaling
- Vascular endothelial growth factor
ASJC Scopus subject areas
- General Agricultural and Biological Sciences
- General Biochemistry, Genetics and Molecular Biology