Receptor for Advanced Glycation End products (RAGE) prevents endothelial cell membrane resealing and regulates F-actin remodeling in a β-catenin-dependent manner

Fei Xiong, Sergey Leonov, Amber Cyan Howard, Shan Xiong, Bin Zhang, Lin Mei, Paul L McNeil, Sylvia Simon, Wencheng Xiong

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: RAGE contributes to the vascular pathology associated with multiple disorders, including Alzheimer disease (AD), diabetic complications, and inflammatory conditions. However, the underlying mechanisms remain largely unknown. Results: RAGE expression in endothelial cells leads to an impaired plasma membrane resealing, altered F-actin remodeling, and increased β-catenin level. Conclusion: Throughβ-catenin, RAGE decreases F-actin stress fibers and prevents endothelial membrane repair in response to the injury. Significance: These results suggest a negative role of RAGE in membrane repair, reveal a new mechanism underlying RAGE regulation of F-actin remodeling, and help our understanding of RAGE involvement in AD and diabetic complication-associated vascular pathology.

Original languageEnglish (US)
Pages (from-to)35061-35070
Number of pages10
JournalJournal of Biological Chemistry
Volume286
Issue number40
DOIs
StatePublished - Oct 7 2011

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Catenins
Endothelial cells
Cell membranes
Actins
Endothelial Cells
Cell Membrane
Pathology
Alzheimer Disease
Repair
Membranes
Diabetic Angiopathies
Stress Fibers
Diabetes Complications
Blood Vessels
Advanced Glycosylation End Product-Specific Receptor
Fibers
Wounds and Injuries

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Receptor for Advanced Glycation End products (RAGE) prevents endothelial cell membrane resealing and regulates F-actin remodeling in a β-catenin-dependent manner. / Xiong, Fei; Leonov, Sergey; Howard, Amber Cyan; Xiong, Shan; Zhang, Bin; Mei, Lin; McNeil, Paul L; Simon, Sylvia; Xiong, Wencheng.

In: Journal of Biological Chemistry, Vol. 286, No. 40, 07.10.2011, p. 35061-35070.

Research output: Contribution to journalArticle

Xiong, Fei ; Leonov, Sergey ; Howard, Amber Cyan ; Xiong, Shan ; Zhang, Bin ; Mei, Lin ; McNeil, Paul L ; Simon, Sylvia ; Xiong, Wencheng. / Receptor for Advanced Glycation End products (RAGE) prevents endothelial cell membrane resealing and regulates F-actin remodeling in a β-catenin-dependent manner. In: Journal of Biological Chemistry. 2011 ; Vol. 286, No. 40. pp. 35061-35070.
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AU - Xiong, Shan

AU - Zhang, Bin

AU - Mei, Lin

AU - McNeil, Paul L

AU - Simon, Sylvia

AU - Xiong, Wencheng

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