Receptor for Advanced Glycation End products (RAGE) prevents endothelial cell membrane resealing and regulates F-actin remodeling in a β-catenin-dependent manner

Fei Xiong, Sergey Leonov, Amber Cyan Howard, Shan Xiong, Bin Zhang, Lin Mei, Paul McNeil, Sylvia Simon, Wen Cheng Xiong

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Background: RAGE contributes to the vascular pathology associated with multiple disorders, including Alzheimer disease (AD), diabetic complications, and inflammatory conditions. However, the underlying mechanisms remain largely unknown. Results: RAGE expression in endothelial cells leads to an impaired plasma membrane resealing, altered F-actin remodeling, and increased β-catenin level. Conclusion: Throughβ-catenin, RAGE decreases F-actin stress fibers and prevents endothelial membrane repair in response to the injury. Significance: These results suggest a negative role of RAGE in membrane repair, reveal a new mechanism underlying RAGE regulation of F-actin remodeling, and help our understanding of RAGE involvement in AD and diabetic complication-associated vascular pathology.

Original languageEnglish (US)
Pages (from-to)35061-35070
Number of pages10
JournalJournal of Biological Chemistry
Volume286
Issue number40
DOIs
StatePublished - Oct 7 2011

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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