TY - JOUR
T1 - Receptor for Advanced Glycation End products (RAGE) prevents endothelial cell membrane resealing and regulates F-actin remodeling in a β-catenin-dependent manner
AU - Xiong, Fei
AU - Leonov, Sergey
AU - Howard, Amber Cyan
AU - Xiong, Shan
AU - Zhang, Bin
AU - Mei, Lin
AU - McNeil, Paul
AU - Simon, Sylvia
AU - Xiong, Wen Cheng
PY - 2011/10/7
Y1 - 2011/10/7
N2 - Background: RAGE contributes to the vascular pathology associated with multiple disorders, including Alzheimer disease (AD), diabetic complications, and inflammatory conditions. However, the underlying mechanisms remain largely unknown. Results: RAGE expression in endothelial cells leads to an impaired plasma membrane resealing, altered F-actin remodeling, and increased β-catenin level. Conclusion: Throughβ-catenin, RAGE decreases F-actin stress fibers and prevents endothelial membrane repair in response to the injury. Significance: These results suggest a negative role of RAGE in membrane repair, reveal a new mechanism underlying RAGE regulation of F-actin remodeling, and help our understanding of RAGE involvement in AD and diabetic complication-associated vascular pathology.
AB - Background: RAGE contributes to the vascular pathology associated with multiple disorders, including Alzheimer disease (AD), diabetic complications, and inflammatory conditions. However, the underlying mechanisms remain largely unknown. Results: RAGE expression in endothelial cells leads to an impaired plasma membrane resealing, altered F-actin remodeling, and increased β-catenin level. Conclusion: Throughβ-catenin, RAGE decreases F-actin stress fibers and prevents endothelial membrane repair in response to the injury. Significance: These results suggest a negative role of RAGE in membrane repair, reveal a new mechanism underlying RAGE regulation of F-actin remodeling, and help our understanding of RAGE involvement in AD and diabetic complication-associated vascular pathology.
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U2 - 10.1074/jbc.M111.261073
DO - 10.1074/jbc.M111.261073
M3 - Article
C2 - 21844192
AN - SCOPUS:80053405714
SN - 0021-9258
VL - 286
SP - 35061
EP - 35070
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 40
ER -