Recipes for creating animal models of diabetic cardiovascular disease

Willa Hsueh, E. Dale Abel, Jan L. Breslow, Nobuyo Maeda, Richard C. Davis, Edward A. Fisher, Hayes Dansky, Donald A. McClain, Richard McIndoe, Momtaz K. Wassef, Cristina Rabadán-Diehl, Ira J. Goldberg

Research output: Contribution to journalReview article

160 Scopus citations

Abstract

For more than 50 years, investigators have unsuccessfully tried to recreate in experimental animals the cardiovascular complications of diabetes seen in humans. In particular, accelerated atherosclerosis and dilated cardiomyopathy, the major causes of mortality in patients with diabetes, have been conspicuously absent in many mouse models of the disease. Under the auspices of the NIH, the Animal Models of Diabetic Complications Consortium has worked to address this issue. This effort has focused on the development of mouse models because of the high level of genomic information available and the many well-developed genetic manipulations that may be performed in mice. Importantly, the consortium has also worked to standardize many methods to assess metabolic and cardiovascular end points for measurement of the diabetic state and its macrovascular complications. Finally, for maximum benefits from these animal models in the study of atherosclerosis and of other diabetic complications, the consortium has created a system for sharing both the animal models and the accumulated phenotypic data with the greater scientific community.

Original languageEnglish (US)
Pages (from-to)1415-1427
Number of pages13
JournalCirculation research
Volume100
Issue number10
DOIs
StatePublished - May 1 2007

Keywords

  • Atherosclerosis
  • Diabetes mellitus
  • Diabetic cardiomyopathy
  • Transgenic mice

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Hsueh, W., Abel, E. D., Breslow, J. L., Maeda, N., Davis, R. C., Fisher, E. A., Dansky, H., McClain, D. A., McIndoe, R., Wassef, M. K., Rabadán-Diehl, C., & Goldberg, I. J. (2007). Recipes for creating animal models of diabetic cardiovascular disease. Circulation research, 100(10), 1415-1427. https://doi.org/10.1161/01.RES.0000266449.37396.1f