Recognition of rabies and rabies-related viruses by T cells derived from human vaccine recipients

Esteban Celis, D. Ou, B. Dietzschold, H. Koprowski

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Human peripheral blood mononuclear cells and T-cell lines and clones from individuals immunized with rabies PM vaccine were tested for the ability to recognize antigenic determinants in rabies and rabies-related viruses in an antigen-induced proliferation assay. Some, but not all, of the T cells from these individuals cross-reacted with various laboratory strains of rabies virus and with rabies-related viruses such as Duvenhage and Mokola. In addition, these T cells were shown to react with epitopes of either the ribonucleoprotein or the viral glycoprotein. Rabies-specific cytotoxic T-cell responses by a CD4+ T-cell line were evident against antigenic determinants of the ribonucleoprotein and glycoprotein.

Original languageEnglish (US)
Pages (from-to)3128-3134
Number of pages7
JournalJournal of Virology
Volume62
Issue number9
StatePublished - Jan 1 1988
Externally publishedYes

Fingerprint

Rabies virus
Rabies
rabies
Vaccines
T-lymphocytes
vaccines
T-Lymphocytes
viruses
epitopes
Epitopes
ribonucleoproteins
Ribonucleoproteins
glycoproteins
Glycoproteins
cell lines
Rabies Vaccines
Cell Line
mononuclear leukocytes
Blood Cells
Clone Cells

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Recognition of rabies and rabies-related viruses by T cells derived from human vaccine recipients. / Celis, Esteban; Ou, D.; Dietzschold, B.; Koprowski, H.

In: Journal of Virology, Vol. 62, No. 9, 01.01.1988, p. 3128-3134.

Research output: Contribution to journalArticle

Celis, Esteban ; Ou, D. ; Dietzschold, B. ; Koprowski, H. / Recognition of rabies and rabies-related viruses by T cells derived from human vaccine recipients. In: Journal of Virology. 1988 ; Vol. 62, No. 9. pp. 3128-3134.
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