Recognition of rabies and rabies-related viruses by T cells derived from human vaccine recipients

E. Celis, D. Ou, B. Dietzschold, H. Koprowski

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Human peripheral blood mononuclear cells and T-cell lines and clones from individuals immunized with rabies PM vaccine were tested for the ability to recognize antigenic determinants in rabies and rabies-related viruses in an antigen-induced proliferation assay. Some, but not all, of the T cells from these individuals cross-reacted with various laboratory strains of rabies virus and with rabies-related viruses such as Duvenhage and Mokola. In addition, these T cells were shown to react with epitopes of either the ribonucleoprotein or the viral glycoprotein. Rabies-specific cytotoxic T-cell responses by a CD4+ T-cell line were evident against antigenic determinants of the ribonucleoprotein and glycoprotein.

Original languageEnglish (US)
Pages (from-to)3128-3134
Number of pages7
JournalJournal of Virology
Volume62
Issue number9
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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