Recommendations for Preclinical Research in Hemorrhagic Transformation

Susan C. Fagan; Paul A. Lapchak; David S. Liebeskind; Tauheed Ishrat; Adviye Ergul

doi:10.1007/s12975-012-0222-5

Recommendations for Preclinical Research in Hemorrhagic Transformation

Susan C. Fagan, Paul A. Lapchak, David S. Liebeskind, Tauheed Ishrat, Adviye Ergul

Physiology

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

Hemorrhagic transformation (HT) is an important complication of ischemic stroke and is responsible for most of the mortality associated with acute reperfusion therapy. Although many important publications address the preclinical models of ischemic stroke, there are no current recommendations on the conduct of research aimed at understanding the mechanisms and consequences of HT. The purpose of this review is to present the various models used in HT research, the clinical correlates, and the experimental variables known to influence the quantitation of HT in preclinical investigation. Lastly, recommendations for the conduct of preclinical research in HT are provided.

Original language	English (US)
Pages (from-to)	322-327
Number of pages	6
Journal	Translational Stroke Research
Volume	4
Issue number	3
DOIs	https://doi.org/10.1007/s12975-012-0222-5
State	Published - Jun 2013

Keywords

Animal models
Hemorrhagic infarction
Hemorrhagic transformation
Ischemic stroke
Tissue plasminogen activator

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology
Cardiology and Cardiovascular Medicine

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10.1007/s12975-012-0222-5

Cite this

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title = "Recommendations for Preclinical Research in Hemorrhagic Transformation",

abstract = "Hemorrhagic transformation (HT) is an important complication of ischemic stroke and is responsible for most of the mortality associated with acute reperfusion therapy. Although many important publications address the preclinical models of ischemic stroke, there are no current recommendations on the conduct of research aimed at understanding the mechanisms and consequences of HT. The purpose of this review is to present the various models used in HT research, the clinical correlates, and the experimental variables known to influence the quantitation of HT in preclinical investigation. Lastly, recommendations for the conduct of preclinical research in HT are provided.",

keywords = "Animal models, Hemorrhagic infarction, Hemorrhagic transformation, Ischemic stroke, Tissue plasminogen activator",

author = "Fagan, {Susan C.} and Lapchak, {Paul A.} and Liebeskind, {David S.} and Tauheed Ishrat and Adviye Ergul",

note = "Funding Information: Acknowledgments This study was supported grants from the National Institutes of Health (SCF, RO1 NS063965; AE, R21 NS070239 DSL P50NS044378, K24NS072272; PAL, U01 NS060685), Veterans Affairs Merit Review (SCF, BX000891; AE, BX000347), and American Heart Association Established Investigator Award (AE, 0740002N).",

year = "2013",

month = jun,

doi = "10.1007/s12975-012-0222-5",

language = "English (US)",

volume = "4",

pages = "322--327",

journal = "Translational Stroke Research",

issn = "1868-4483",

publisher = "Springer US",

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T1 - Recommendations for Preclinical Research in Hemorrhagic Transformation

AU - Fagan, Susan C.

AU - Lapchak, Paul A.

AU - Liebeskind, David S.

AU - Ishrat, Tauheed

AU - Ergul, Adviye

N1 - Funding Information: Acknowledgments This study was supported grants from the National Institutes of Health (SCF, RO1 NS063965; AE, R21 NS070239 DSL P50NS044378, K24NS072272; PAL, U01 NS060685), Veterans Affairs Merit Review (SCF, BX000891; AE, BX000347), and American Heart Association Established Investigator Award (AE, 0740002N).

PY - 2013/6

Y1 - 2013/6

N2 - Hemorrhagic transformation (HT) is an important complication of ischemic stroke and is responsible for most of the mortality associated with acute reperfusion therapy. Although many important publications address the preclinical models of ischemic stroke, there are no current recommendations on the conduct of research aimed at understanding the mechanisms and consequences of HT. The purpose of this review is to present the various models used in HT research, the clinical correlates, and the experimental variables known to influence the quantitation of HT in preclinical investigation. Lastly, recommendations for the conduct of preclinical research in HT are provided.

AB - Hemorrhagic transformation (HT) is an important complication of ischemic stroke and is responsible for most of the mortality associated with acute reperfusion therapy. Although many important publications address the preclinical models of ischemic stroke, there are no current recommendations on the conduct of research aimed at understanding the mechanisms and consequences of HT. The purpose of this review is to present the various models used in HT research, the clinical correlates, and the experimental variables known to influence the quantitation of HT in preclinical investigation. Lastly, recommendations for the conduct of preclinical research in HT are provided.

KW - Animal models

KW - Hemorrhagic infarction

KW - Hemorrhagic transformation

KW - Ischemic stroke

KW - Tissue plasminogen activator

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Recommendations for Preclinical Research in Hemorrhagic Transformation

Abstract

Keywords

ASJC Scopus subject areas

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