Rectal Adenocarcinoma with Germ-Cell Differentiation: Report of a Case

Teresa A. Coleman; Charles D. Redger; Randy L. Hamill; Paul M Dainer

doi:10.1007/BF02660779

Rectal Adenocarcinoma with Germ-Cell Differentiation: Report of a Case

Teresa A. Coleman, Charles D. Redger, Randy L. Hamill, Paul M Dainer

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A 26-year-old male presented with a colorectal adenocarcinoma with germ-cell differentiation and an isolated elevation of serum alpha-fetoprotein. He was treated with platinum/etoposide/bleomycin chemotherapy with a decrease in serum alpha-fetoprotein and in the size of the primary tumor. An ongoing tumor-marker response occurred when the patient was switched to concurrent 5-fluorouracil chemotherapy and radiation therapy. The patient underwent a palliative diversion of his rectal cancer 10 months after diagnosis, developed liver metastasis at 12 months, and died 20 months after diagnosis.

Original language	English (US)
Pages (from-to)	1702-1705
Number of pages	4
Journal	Diseases of the Colon and Rectum
Volume	46
Issue number	12
DOIs	https://doi.org/10.1007/BF02660779
State	Published - Dec 2003
Externally published	Yes

Keywords

Alpha-fetoprotein
Colorectal carcinoma
Germ-cell differentiation
Platinum/etoposide/ bleomycin chemotherapy

ASJC Scopus subject areas

Gastroenterology

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10.1007/BF02660779

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title = "Rectal Adenocarcinoma with Germ-Cell Differentiation: Report of a Case",

abstract = "A 26-year-old male presented with a colorectal adenocarcinoma with germ-cell differentiation and an isolated elevation of serum alpha-fetoprotein. He was treated with platinum/etoposide/bleomycin chemotherapy with a decrease in serum alpha-fetoprotein and in the size of the primary tumor. An ongoing tumor-marker response occurred when the patient was switched to concurrent 5-fluorouracil chemotherapy and radiation therapy. The patient underwent a palliative diversion of his rectal cancer 10 months after diagnosis, developed liver metastasis at 12 months, and died 20 months after diagnosis.",

keywords = "Alpha-fetoprotein, Colorectal carcinoma, Germ-cell differentiation, Platinum/etoposide/ bleomycin chemotherapy",

author = "Coleman, {Teresa A.} and Redger, {Charles D.} and Hamill, {Randy L.} and Dainer, {Paul M}",

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AU - Redger, Charles D.

AU - Hamill, Randy L.

AU - Dainer, Paul M

PY - 2003/12

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N2 - A 26-year-old male presented with a colorectal adenocarcinoma with germ-cell differentiation and an isolated elevation of serum alpha-fetoprotein. He was treated with platinum/etoposide/bleomycin chemotherapy with a decrease in serum alpha-fetoprotein and in the size of the primary tumor. An ongoing tumor-marker response occurred when the patient was switched to concurrent 5-fluorouracil chemotherapy and radiation therapy. The patient underwent a palliative diversion of his rectal cancer 10 months after diagnosis, developed liver metastasis at 12 months, and died 20 months after diagnosis.

AB - A 26-year-old male presented with a colorectal adenocarcinoma with germ-cell differentiation and an isolated elevation of serum alpha-fetoprotein. He was treated with platinum/etoposide/bleomycin chemotherapy with a decrease in serum alpha-fetoprotein and in the size of the primary tumor. An ongoing tumor-marker response occurred when the patient was switched to concurrent 5-fluorouracil chemotherapy and radiation therapy. The patient underwent a palliative diversion of his rectal cancer 10 months after diagnosis, developed liver metastasis at 12 months, and died 20 months after diagnosis.

KW - Alpha-fetoprotein

KW - Colorectal carcinoma

KW - Germ-cell differentiation

KW - Platinum/etoposide/ bleomycin chemotherapy

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