Rectal Adenocarcinoma with Germ-Cell Differentiation: Report of a Case

Teresa A. Coleman, Charles D. Redger, Randy L. Hamill, Paul M Dainer

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A 26-year-old male presented with a colorectal adenocarcinoma with germ-cell differentiation and an isolated elevation of serum alpha-fetoprotein. He was treated with platinum/etoposide/bleomycin chemotherapy with a decrease in serum alpha-fetoprotein and in the size of the primary tumor. An ongoing tumor-marker response occurred when the patient was switched to concurrent 5-fluorouracil chemotherapy and radiation therapy. The patient underwent a palliative diversion of his rectal cancer 10 months after diagnosis, developed liver metastasis at 12 months, and died 20 months after diagnosis.

Original languageEnglish (US)
Pages (from-to)1702-1705
Number of pages4
JournalDiseases of the Colon and Rectum
Volume46
Issue number12
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

Fingerprint

alpha-Fetoproteins
Germ Cells
Cell Differentiation
Adenocarcinoma
Drug Therapy
Bleomycin
Etoposide
Rectal Neoplasms
Tumor Biomarkers
Platinum
Serum
Fluorouracil
Radiotherapy
Neoplasm Metastasis
Liver
Neoplasms

Keywords

  • Alpha-fetoprotein
  • Colorectal carcinoma
  • Germ-cell differentiation
  • Platinum/etoposide/ bleomycin chemotherapy

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Rectal Adenocarcinoma with Germ-Cell Differentiation : Report of a Case. / Coleman, Teresa A.; Redger, Charles D.; Hamill, Randy L.; Dainer, Paul M.

In: Diseases of the Colon and Rectum, Vol. 46, No. 12, 01.01.2003, p. 1702-1705.

Research output: Contribution to journalArticle

Coleman, Teresa A. ; Redger, Charles D. ; Hamill, Randy L. ; Dainer, Paul M. / Rectal Adenocarcinoma with Germ-Cell Differentiation : Report of a Case. In: Diseases of the Colon and Rectum. 2003 ; Vol. 46, No. 12. pp. 1702-1705.
@article{11a04af1229d4d979719be0674f9942b,
title = "Rectal Adenocarcinoma with Germ-Cell Differentiation: Report of a Case",
abstract = "A 26-year-old male presented with a colorectal adenocarcinoma with germ-cell differentiation and an isolated elevation of serum alpha-fetoprotein. He was treated with platinum/etoposide/bleomycin chemotherapy with a decrease in serum alpha-fetoprotein and in the size of the primary tumor. An ongoing tumor-marker response occurred when the patient was switched to concurrent 5-fluorouracil chemotherapy and radiation therapy. The patient underwent a palliative diversion of his rectal cancer 10 months after diagnosis, developed liver metastasis at 12 months, and died 20 months after diagnosis.",
keywords = "Alpha-fetoprotein, Colorectal carcinoma, Germ-cell differentiation, Platinum/etoposide/ bleomycin chemotherapy",
author = "Coleman, {Teresa A.} and Redger, {Charles D.} and Hamill, {Randy L.} and Dainer, {Paul M}",
year = "2003",
month = "1",
day = "1",
doi = "10.1007/BF02660779",
language = "English (US)",
volume = "46",
pages = "1702--1705",
journal = "Diseases of the Colon and Rectum",
issn = "0012-3706",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

TY - JOUR

T1 - Rectal Adenocarcinoma with Germ-Cell Differentiation

T2 - Report of a Case

AU - Coleman, Teresa A.

AU - Redger, Charles D.

AU - Hamill, Randy L.

AU - Dainer, Paul M

PY - 2003/1/1

Y1 - 2003/1/1

N2 - A 26-year-old male presented with a colorectal adenocarcinoma with germ-cell differentiation and an isolated elevation of serum alpha-fetoprotein. He was treated with platinum/etoposide/bleomycin chemotherapy with a decrease in serum alpha-fetoprotein and in the size of the primary tumor. An ongoing tumor-marker response occurred when the patient was switched to concurrent 5-fluorouracil chemotherapy and radiation therapy. The patient underwent a palliative diversion of his rectal cancer 10 months after diagnosis, developed liver metastasis at 12 months, and died 20 months after diagnosis.

AB - A 26-year-old male presented with a colorectal adenocarcinoma with germ-cell differentiation and an isolated elevation of serum alpha-fetoprotein. He was treated with platinum/etoposide/bleomycin chemotherapy with a decrease in serum alpha-fetoprotein and in the size of the primary tumor. An ongoing tumor-marker response occurred when the patient was switched to concurrent 5-fluorouracil chemotherapy and radiation therapy. The patient underwent a palliative diversion of his rectal cancer 10 months after diagnosis, developed liver metastasis at 12 months, and died 20 months after diagnosis.

KW - Alpha-fetoprotein

KW - Colorectal carcinoma

KW - Germ-cell differentiation

KW - Platinum/etoposide/ bleomycin chemotherapy

UR - http://www.scopus.com/inward/record.url?scp=0346780670&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0346780670&partnerID=8YFLogxK

U2 - 10.1007/BF02660779

DO - 10.1007/BF02660779

M3 - Article

C2 - 14668599

AN - SCOPUS:0346780670

VL - 46

SP - 1702

EP - 1705

JO - Diseases of the Colon and Rectum

JF - Diseases of the Colon and Rectum

SN - 0012-3706

IS - 12

ER -