Rectoanal reflexes and sensorimotor response in rectal hyposensitivity

Jose M. Remes-Troche, Sherrie De-Ocampo, Jessica Valestin, Satish Sanku Chander Rao

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

PURPOSE: Rectal hyposensitivity commonly causes anorectal disorders, but its underlying mechanism is unknown. We hypothesized that subjects with rectal hyposensitivity have altered rectoanal reflexes and/or sensorimotor response. METHODS: We performed stepwise graded balloon distensions of the rectum in 30 subjects with constipation and rectal hyposensitivity and in 23 healthy controls. Thresholds for first sensation, desire, and urgency to defecate were assessed. The lowest balloon volume that evoked rectoanal inhibitory reflex, rectoanal contractile reflex, and sensorimotor response and manometric characteristics and rectal compliance were examined. RESULTS: Reflex responses were present in all subjects. The balloon volumes were higher in subjects with rectal hyposensitivity for inducing rectoanal inhibitory reflex (P = .008) and contractile reflex (P = .001) compared with controls. All controls showed a sensorimotor response, but in 13 hyposensitive subjects (43%) the onset of sensorimotor response was associated with absent sensation and in 17 (57%), with a transient rectal sensation. Thresholds for eliciting sensorimotor response were similar between patients and controls, but the amplitude, duration, and magnitude of response were higher (P < .05) in patients. Rectal compliance was similar between controls and hyposensitive subjects with transient sensation but higher (P = .001) in subjects with absent sensation. CONCLUSIONS: Constipated subjects with rectal hyposensitivity demonstrate higher thresholds for inducing rectoanal reflexes and abnormal characteristics of sensorimotor response. These findings suggest either disruption of afferent gut-brain pathways or rectal wall dysfunction. These altered features may play a role in the pathogenesis of bowel dysfunction in rectal hyposensitivity.

Original languageEnglish (US)
Pages (from-to)1047-1054
Number of pages8
JournalDiseases of the Colon and Rectum
Volume53
Issue number7
DOIs
StatePublished - Jul 1 2010

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Reflex
Compliance
Rectal Diseases
Abnormal Reflexes
Constipation
Rectum
Brain

Keywords

  • Rectal hyposensitivity
  • Rectoanal contractile reflex
  • Rectoanal inhibitory reflex
  • Sensorimotor response

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Rectoanal reflexes and sensorimotor response in rectal hyposensitivity. / Remes-Troche, Jose M.; De-Ocampo, Sherrie; Valestin, Jessica; Rao, Satish Sanku Chander.

In: Diseases of the Colon and Rectum, Vol. 53, No. 7, 01.07.2010, p. 1047-1054.

Research output: Contribution to journalArticle

Remes-Troche, Jose M. ; De-Ocampo, Sherrie ; Valestin, Jessica ; Rao, Satish Sanku Chander. / Rectoanal reflexes and sensorimotor response in rectal hyposensitivity. In: Diseases of the Colon and Rectum. 2010 ; Vol. 53, No. 7. pp. 1047-1054.
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