Redox control of vascular smooth muscle proliferation

Kathy K. Griendling, Masuko Fukai

Research output: Contribution to journalReview article

173 Citations (Scopus)

Abstract

Recent evidence suggests a role for reactive oxygen species in the control of vascular smooth muscle proliferation both in vitro and in vivo. Oxidative stress increases cell proliferation, mediates hormone-induced hypertrophy, and under some circumstances-induces apoptosis. Smooth muscle cells contain a reduced nicotinamide adenine dinucleotide/reduced nicotinamide adenine dinucleotide phosphate oxidase that is responsible for the majority of the superoxide produced by the vessel wall. This enzyme has been characterized biochemically, but only limited information is available regarding its molecular structure. High levels of oxidative stress are apparently involved in the pathogenesis of vascular diseases such as hypertension and atherosclerosis, along with abnormal vascular growth after balloon injury. Thus the pathways responsible for oxidative stress, as well as the antioxidant defenses in the vessel wall, may provide novel therapeutic targets.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalJournal of Laboratory and Clinical Medicine
Volume132
Issue number1
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

Fingerprint

Oxidative stress
Vascular Smooth Muscle
Oxidation-Reduction
Muscle
Oxidative Stress
Balloons
Cell proliferation
Molecular Structure
NADP
Vascular Diseases
Superoxides
NAD
Hypertrophy
Molecular structure
Smooth Muscle Myocytes
Blood Vessels
Reactive Oxygen Species
Atherosclerosis
Oxidoreductases
Antioxidants

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Redox control of vascular smooth muscle proliferation. / Griendling, Kathy K.; Fukai, Masuko.

In: Journal of Laboratory and Clinical Medicine, Vol. 132, No. 1, 01.01.1998, p. 9-15.

Research output: Contribution to journalReview article

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