Reelin signaling in development, maintenance, and plasticity of neural networks

Research output: Contribution to journalReview article

42 Citations (Scopus)

Abstract

The developing brain is formed through an orchestrated pattern of neuronal migration, leading to the formation of heterogeneous functional regions in the adult. Several proteins and pathways have been identified as mediators of developmental neuronal migration and cell positioning. However, these pathways do not cease to be functionally relevant after the embryonic and early postnatal period; instead, they switch from guiding cells, to guiding synapses. The outcome of synaptic guidance determines the strength and plasticity of neuronal networks by creating a scalable functional architecture that is sculpted by cues from the internal and external environment. Reelin is a multifunctional signal that coordinates cortical and subcortical morphogenesis during development and regulates structural plasticity in adulthood and aging. Gain or loss of function in reelin or its receptors has the potential to influence synaptic strength and patterns of connectivity, with consequences for memory and cognition. The current review highlights similarities in the signaling cascades that modulate neuronal positioning during development, and synaptic plasticity in the adult, with a focus on reelin, a glycoprotein that is increasingly recognized for its dual role in the formation and maintenance of neural circuits.

Original languageEnglish (US)
Pages (from-to)815-822
Number of pages8
JournalAgeing Research Reviews
Volume12
Issue number3
DOIs
StatePublished - Jun 1 2013

Fingerprint

Neuronal Plasticity
Plasticity
Maintenance
Neural networks
Morphogenesis
Synapses
Cognition
Cell Movement
Cues
Glycoproteins
Brain
Aging of materials
Switches
Data storage equipment
Proteins
Networks (circuits)

Keywords

  • Apolipoprotein E receptor 2
  • Disabled-1
  • Hippocampus
  • Long-term potentiation
  • Reelin
  • Very low density lipoprotein receptor

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Aging
  • Molecular Biology
  • Neurology

Cite this

Reelin signaling in development, maintenance, and plasticity of neural networks. / Stranahan, Alexis Michelle; Appel, Joanna Ruth; Wosiski-Kuhn, Marlena.

In: Ageing Research Reviews, Vol. 12, No. 3, 01.06.2013, p. 815-822.

Research output: Contribution to journalReview article

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