Regadenoson: A New Myocardial Stress Agent

Wael Al Jaroudi, Ami E. Iskandrian

Research output: Contribution to journalReview articlepeer-review

139 Scopus citations

Abstract

Vasodilator stress myocardial perfusion imaging (MPI) accounts for up to 50% of all stress MPI studies performed in the U.S. In 2008, the Food and Drug Administration approved regadenoson for stress testing in conjunction with MPI. Regadenoson, unlike adenosine, is a selective A2A agonist that is given as an intravenous bolus at a fixed dose, with less undesirable side effects including atrioventricular block and bronchospasm. Unlike adenosine, regadenoson could be used in patients with mild-to-moderate reactive airway disease. This review will summarize the pre-clinical and clinical data on regadenoson, as they specifically relate to its use as a vasodilator stress agent, currently the only approved selective A2A agonist..

Original languageEnglish (US)
Pages (from-to)1123-1130
Number of pages8
JournalJournal of the American College of Cardiology
Volume54
Issue number13
DOIs
StatePublished - Sep 22 2009
Externally publishedYes

Keywords

  • adenosine
  • myocardial perfusion imaging
  • regadenoson
  • single-photon emission computed tomography
  • stress testing

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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