Regional gastrointestinal transit and pH studied in 215 healthy volunteers using the wireless motility capsule

Influence of age, gender, study country and testing protocol

Y. T. Wang, S. D. Mohammed, A. D. Farmer, D. Wang, N. Zarate, A. R. Hobson, P. M. Hellström, J. R. Semler, B. Kuo, Satish Sanku Chander Rao, W. L. Hasler, M. Camilleri, S. M. Scott

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background The wireless motility capsule (WMC) offers the ability to investigate luminal gastrointestinal (GI) physiology in a minimally invasive manner. Aim To investigate the effect of testing protocol, gender, age and study country on regional GI transit times and associated pH values using the WMC. Methods Regional GI transit times and pH values were determined in 215 healthy volunteers from USA and Sweden studied using the WMC over a 6.5-year period. The effects of test protocol, gender, age and study country were examined. Results For GI transit times, testing protocol was associated with differences in gastric emptying time (GET; shorter with protocol 2 (motility capsule ingested immediately after meal) vs. protocol 1 (motility capsule immediately before): median difference: 52 min, P = 0.0063) and colonic transit time (CTT; longer with protocol 2: median 140 min, P = 0.0189), but had no overall effect on whole gut transit time. Females had longer GET (by median 17 min, P = 0.0307), and also longer CTT by (104 min, P = 0.0285) and whole gut transit time by (263 min, P = 0.0077). Increasing age was associated with shorter small bowel transit time (P = 0.002), and study country also influenced small bowel and CTTs. Whole gut and CTTs showed clustering of data at values separated by 24 h, suggesting that describing these measures as continuous variables is invalid. Testing protocol, gender and study country also significantly influenced pH values. Conclusions Regional GI transit times and pH values, delineated using the wireless motility capsule (WMC), vary based on testing protocol, gender, age and country. Standardisation of testing is crucial for cross-referencing in clinical practice and future research.

Original languageEnglish (US)
Pages (from-to)761-772
Number of pages12
JournalAlimentary Pharmacology and Therapeutics
Volume42
Issue number6
DOIs
StatePublished - Sep 1 2015

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Gastrointestinal Transit
Capsules
Healthy Volunteers
Gastric Emptying
Sweden
Cluster Analysis
Meals

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)

Cite this

Regional gastrointestinal transit and pH studied in 215 healthy volunteers using the wireless motility capsule : Influence of age, gender, study country and testing protocol. / Wang, Y. T.; Mohammed, S. D.; Farmer, A. D.; Wang, D.; Zarate, N.; Hobson, A. R.; Hellström, P. M.; Semler, J. R.; Kuo, B.; Rao, Satish Sanku Chander; Hasler, W. L.; Camilleri, M.; Scott, S. M.

In: Alimentary Pharmacology and Therapeutics, Vol. 42, No. 6, 01.09.2015, p. 761-772.

Research output: Contribution to journalArticle

Wang, YT, Mohammed, SD, Farmer, AD, Wang, D, Zarate, N, Hobson, AR, Hellström, PM, Semler, JR, Kuo, B, Rao, SSC, Hasler, WL, Camilleri, M & Scott, SM 2015, 'Regional gastrointestinal transit and pH studied in 215 healthy volunteers using the wireless motility capsule: Influence of age, gender, study country and testing protocol', Alimentary Pharmacology and Therapeutics, vol. 42, no. 6, pp. 761-772. https://doi.org/10.1111/apt.13329
Wang, Y. T. ; Mohammed, S. D. ; Farmer, A. D. ; Wang, D. ; Zarate, N. ; Hobson, A. R. ; Hellström, P. M. ; Semler, J. R. ; Kuo, B. ; Rao, Satish Sanku Chander ; Hasler, W. L. ; Camilleri, M. ; Scott, S. M. / Regional gastrointestinal transit and pH studied in 215 healthy volunteers using the wireless motility capsule : Influence of age, gender, study country and testing protocol. In: Alimentary Pharmacology and Therapeutics. 2015 ; Vol. 42, No. 6. pp. 761-772.
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abstract = "Background The wireless motility capsule (WMC) offers the ability to investigate luminal gastrointestinal (GI) physiology in a minimally invasive manner. Aim To investigate the effect of testing protocol, gender, age and study country on regional GI transit times and associated pH values using the WMC. Methods Regional GI transit times and pH values were determined in 215 healthy volunteers from USA and Sweden studied using the WMC over a 6.5-year period. The effects of test protocol, gender, age and study country were examined. Results For GI transit times, testing protocol was associated with differences in gastric emptying time (GET; shorter with protocol 2 (motility capsule ingested immediately after meal) vs. protocol 1 (motility capsule immediately before): median difference: 52 min, P = 0.0063) and colonic transit time (CTT; longer with protocol 2: median 140 min, P = 0.0189), but had no overall effect on whole gut transit time. Females had longer GET (by median 17 min, P = 0.0307), and also longer CTT by (104 min, P = 0.0285) and whole gut transit time by (263 min, P = 0.0077). Increasing age was associated with shorter small bowel transit time (P = 0.002), and study country also influenced small bowel and CTTs. Whole gut and CTTs showed clustering of data at values separated by 24 h, suggesting that describing these measures as continuous variables is invalid. Testing protocol, gender and study country also significantly influenced pH values. Conclusions Regional GI transit times and pH values, delineated using the wireless motility capsule (WMC), vary based on testing protocol, gender, age and country. Standardisation of testing is crucial for cross-referencing in clinical practice and future research.",
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T2 - Influence of age, gender, study country and testing protocol

AU - Wang, Y. T.

AU - Mohammed, S. D.

AU - Farmer, A. D.

AU - Wang, D.

AU - Zarate, N.

AU - Hobson, A. R.

AU - Hellström, P. M.

AU - Semler, J. R.

AU - Kuo, B.

AU - Rao, Satish Sanku Chander

AU - Hasler, W. L.

AU - Camilleri, M.

AU - Scott, S. M.

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N2 - Background The wireless motility capsule (WMC) offers the ability to investigate luminal gastrointestinal (GI) physiology in a minimally invasive manner. Aim To investigate the effect of testing protocol, gender, age and study country on regional GI transit times and associated pH values using the WMC. Methods Regional GI transit times and pH values were determined in 215 healthy volunteers from USA and Sweden studied using the WMC over a 6.5-year period. The effects of test protocol, gender, age and study country were examined. Results For GI transit times, testing protocol was associated with differences in gastric emptying time (GET; shorter with protocol 2 (motility capsule ingested immediately after meal) vs. protocol 1 (motility capsule immediately before): median difference: 52 min, P = 0.0063) and colonic transit time (CTT; longer with protocol 2: median 140 min, P = 0.0189), but had no overall effect on whole gut transit time. Females had longer GET (by median 17 min, P = 0.0307), and also longer CTT by (104 min, P = 0.0285) and whole gut transit time by (263 min, P = 0.0077). Increasing age was associated with shorter small bowel transit time (P = 0.002), and study country also influenced small bowel and CTTs. Whole gut and CTTs showed clustering of data at values separated by 24 h, suggesting that describing these measures as continuous variables is invalid. Testing protocol, gender and study country also significantly influenced pH values. Conclusions Regional GI transit times and pH values, delineated using the wireless motility capsule (WMC), vary based on testing protocol, gender, age and country. Standardisation of testing is crucial for cross-referencing in clinical practice and future research.

AB - Background The wireless motility capsule (WMC) offers the ability to investigate luminal gastrointestinal (GI) physiology in a minimally invasive manner. Aim To investigate the effect of testing protocol, gender, age and study country on regional GI transit times and associated pH values using the WMC. Methods Regional GI transit times and pH values were determined in 215 healthy volunteers from USA and Sweden studied using the WMC over a 6.5-year period. The effects of test protocol, gender, age and study country were examined. Results For GI transit times, testing protocol was associated with differences in gastric emptying time (GET; shorter with protocol 2 (motility capsule ingested immediately after meal) vs. protocol 1 (motility capsule immediately before): median difference: 52 min, P = 0.0063) and colonic transit time (CTT; longer with protocol 2: median 140 min, P = 0.0189), but had no overall effect on whole gut transit time. Females had longer GET (by median 17 min, P = 0.0307), and also longer CTT by (104 min, P = 0.0285) and whole gut transit time by (263 min, P = 0.0077). Increasing age was associated with shorter small bowel transit time (P = 0.002), and study country also influenced small bowel and CTTs. Whole gut and CTTs showed clustering of data at values separated by 24 h, suggesting that describing these measures as continuous variables is invalid. Testing protocol, gender and study country also significantly influenced pH values. Conclusions Regional GI transit times and pH values, delineated using the wireless motility capsule (WMC), vary based on testing protocol, gender, age and country. Standardisation of testing is crucial for cross-referencing in clinical practice and future research.

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