Regional localization of 192 genic markers on human chromosome 1

Terry Roberts; Charles Auffray; John K. Cowell

doi:10.1006/geno.1996.0470

Regional localization of 192 genic markers on human chromosome 1

Terry Roberts, Charles Auffray, John K. Cowell

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A panel of somatic cell hybrids has been used to localize 192 novel eSTS markers to seven individual subregions of human chromosome 1. The positions of the breakpoints in each of these hybrids have been determined relative to the genetic linkage map of chromosome 1, and so the approximate locations of the genes from which the eSTS markers have been derived can be determined. Although the distribution of the eSTS markers is relatively random, 23% were assigned to the 1p34-p36 region. The hybrid mapping panel does not subdivide the 1q24-q44 region, which contains 36% of the eSTS markers. This analysis, therefore, provides a series of genic markers in which to search for candidates for a variety of human genetic disorders and recessive oncogenes mapped to the same relative position on the chromosome.

Original language	English (US)
Pages (from-to)	337-340
Number of pages	4
Journal	Genomics
Volume	36
Issue number	2
DOIs	https://doi.org/10.1006/geno.1996.0470
State	Published - Sep 1 1996
Externally published	Yes

ASJC Scopus subject areas

Genetics

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10.1006/geno.1996.0470

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@article{5791cdc157a74075892abdb360d1e9c9,

title = "Regional localization of 192 genic markers on human chromosome 1",

abstract = "A panel of somatic cell hybrids has been used to localize 192 novel eSTS markers to seven individual subregions of human chromosome 1. The positions of the breakpoints in each of these hybrids have been determined relative to the genetic linkage map of chromosome 1, and so the approximate locations of the genes from which the eSTS markers have been derived can be determined. Although the distribution of the eSTS markers is relatively random, 23% were assigned to the 1p34-p36 region. The hybrid mapping panel does not subdivide the 1q24-q44 region, which contains 36% of the eSTS markers. This analysis, therefore, provides a series of genic markers in which to search for candidates for a variety of human genetic disorders and recessive oncogenes mapped to the same relative position on the chromosome.",

author = "Terry Roberts and Charles Auffray and Cowell, {John K.}",

note = "Funding Information: We thank Nicolas Vignier, Bernard Prudhon, and Re{\^A}gine Mariage-Samson for their assistance in this work. The Genexpress Program was supported by the Centre National de la Recherche Scienti{\textregistered}que (CNRS), by the Association Francaise Centre les Myopathies (AFM), and by grants from the European Union Biomed 1 Program to C.A. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "1996",

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doi = "10.1006/geno.1996.0470",

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AU - Roberts, Terry

AU - Auffray, Charles

AU - Cowell, John K.

N1 - Funding Information: We thank Nicolas Vignier, Bernard Prudhon, and ReÂgine Mariage-Samson for their assistance in this work. The Genexpress Program was supported by the Centre National de la Recherche Scienti®que (CNRS), by the Association Francaise Centre les Myopathies (AFM), and by grants from the European Union Biomed 1 Program to C.A. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 1996/9/1

Y1 - 1996/9/1

N2 - A panel of somatic cell hybrids has been used to localize 192 novel eSTS markers to seven individual subregions of human chromosome 1. The positions of the breakpoints in each of these hybrids have been determined relative to the genetic linkage map of chromosome 1, and so the approximate locations of the genes from which the eSTS markers have been derived can be determined. Although the distribution of the eSTS markers is relatively random, 23% were assigned to the 1p34-p36 region. The hybrid mapping panel does not subdivide the 1q24-q44 region, which contains 36% of the eSTS markers. This analysis, therefore, provides a series of genic markers in which to search for candidates for a variety of human genetic disorders and recessive oncogenes mapped to the same relative position on the chromosome.

AB - A panel of somatic cell hybrids has been used to localize 192 novel eSTS markers to seven individual subregions of human chromosome 1. The positions of the breakpoints in each of these hybrids have been determined relative to the genetic linkage map of chromosome 1, and so the approximate locations of the genes from which the eSTS markers have been derived can be determined. Although the distribution of the eSTS markers is relatively random, 23% were assigned to the 1p34-p36 region. The hybrid mapping panel does not subdivide the 1q24-q44 region, which contains 36% of the eSTS markers. This analysis, therefore, provides a series of genic markers in which to search for candidates for a variety of human genetic disorders and recessive oncogenes mapped to the same relative position on the chromosome.

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DO - 10.1006/geno.1996.0470

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JO - Genomics

JF - Genomics

IS - 2

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Regional localization of 192 genic markers on human chromosome 1

Abstract

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