Regional subacute cranial neuropathies following internal carotid cisplatin infusion

Lloyd M. Alderson, Patrick T. Noonan, In Sup Choi, John W. Henson

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The inferolateral trunk arises from the internal carotid artery at C-4 and provides vascular supply to cranial nerves III to VI. We report a patient who developed neuropathies of cranial nerves III, V1-3, and VI, 48 hours after infusion of cisplatin into the right internal carotid artery for an anaplastic oligoastrocytoma. The clinical and radiographic findings implicated direct toxicity to nerves in the distribution of the inferolateral trunk. We found additional cases by review of published brain tumor chemotherapy trials, thus identifying a novel, toxic neurovascular mechanism for injury to cranial nerves III to VI.

Original languageEnglish (US)
Pages (from-to)1088-1090
Number of pages3
JournalNeurology
Volume47
Issue number4
DOIs
StatePublished - Oct 1996
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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